Skip to main content

EN
ÍS

Forsíða

Forsíða

Snævar Sigurðsson - Sérfræðingur

Snævar Sigurðsson

–

Heilbrigðisvísindasvið

Snævar Sigurðsson

Sérfræðingur

Aðsetur
Læknagarður / Lg-456
Tölvupóstur
snaevar [hjá] hi.is

Starfseining
Lífvísindasetur

ORCID vefsíða
https://orcid.org/0000-0003-4860-6311
Rannsóknagátt – Snævar Sigurðsson

Útgefið efni

2023

Aroylated phenylenediamine HO53 modulates innate immunity, histone acetylation and metabolismMolecular Immunology
Evaluating Prophylactic Effect of Bovine Colostrum on Intestinal Barrier Function in Zonulin Transgenic MiceInternational Journal of Molecular Sciences

2022

Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse modelLaboratory Animal Research
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial CellsJournal of Innate Immunity

2021

Metabolic and transcriptional changes across osteogenic differentiation of mesenchymal stromal cellsBioengineering

2020

Azithromycin has lung barrier protective effects in a cell model mimicking ventilator-induced lung injuryAltex
Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responsesRespiratory Research
Common and rare sequence variants influencing tumor biomarkers in bloodCancer Epidemiology Biomarkers and Prevention

2017

Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitisNature Communications
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritabilityNature Genetics

2014

Rare mutations associating with serum creatinine and chronic kidney diseaseHuman Molecular Genetics
Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorderGenome Biology
Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24PLoS Genetics

2013

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4Annals of the Rheumatic Diseases
Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencingNature Genetics
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/BGenome Biology

2012

Copy number expansion of the STX17 duplication in melanoma tissue from Grey horses.BMC Genomics

2011

A candidate gene study of the type i interferon pathway implicates IKBKE and IL8 as risk loci for SLEEuropean Journal of Human Genetics
Identification of genomic regions associated with phenotypic variation between dog breeds using selection mappingPLoS Genetics
Performance of microarray and liquid based capture methods for target enrichment for massively parallel sequencing and SNP discoveryPLoS ONE
Mutation discovery in mice by whole exome sequencingGenome Biology

2010

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosusArthritis and Rheumatism
Fine-mapping and mutation analysis of TRPM1Briefings in Functional Genomics and Proteomics
A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosusAnnals of the Rheumatic Diseases
Identification of the bovine arachnomelia mutation by massively parallel sequencing implicates sulfite oxidase (SUOX) in bone developmentPLoS Genetics

2009

Genome sequence, comparative analysis, and population genetics of the domestic horseScience

2008

Variants of the interferon regulatory factor 5 gene regulate expression of IRF5 mRNA in atherosclerotic tissue but are not associated with myocardial infarctionArteriosclerosis, Thrombosis, and Vascular Biology
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosusHuman Molecular Genetics
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populationsJournal of Medical Genetics
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5Human Molecular Genetics

2007

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupusProceedings of the National Academy of Sciences of the United States of America
Corrigendum to ''A microarray system for genotyping 150 single nucleotide polymorphisms in the coding region of human mitochondrial DNA" [Genomics 87 (2006) 534-542] (DOI:10.1016/j.ygeno.2005.11.022)Genomics
An insertion-deletion polymorphism in the Interferon Regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseasesHuman Molecular Genetics
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritisArthritis and Rheumatism

2006

A microarray system for genotyping 150 single nucleotide polymorphisms in the coding region of human mitochondrial DNAGenomics
Genotyping of Single Nucleotide Polymorphisms by Minisequencing Using Tag Arrays

2005

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosusAmerican Journal of Human Genetics

2003

Quantitative evaluation by minisequencing and microarrays reveals accurate multiplexed SNP genotyping of whole genome amplified DNANucleic Acids Research

2002

Multiplex SNP genotyping in pooled DNA samples by a four-colour microarray system.Nucleic Acids Research

Sérsvið:

Lífupplýsingafræði