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Magnús Karl Magnússon - Prófessor

Magnús Karl Magnússon

–

Heilbrigðisvísindasvið

Magnús Karl Magnússon

Prófessor

Prófessor, Læknadeild

Aðsetur
Sturlugata 8
Tölvupóstur
magnuskm [hjá] hi.is

Starfseining
Læknadeild
Vefsíða
https://magnuskm.hi.is

ORCID vefsíða
https://orcid.org/0000-0001-8593-4934
Rannsóknagátt – Magnús Karl Magnússon

Útgefið efni

2025

The association between elevated preoperative red cell distribution width and worsening kidney function after noncardiac operation. A propensity score and competing risk weighted retrospective cohort studyBJA Open

2024

The Nobel prize in medicine - microRNA and gene regulationLaeknabladid
Correction toNature
Novel loci and biomedical consequences of iron homoeostasis variationCommunications Biology
Understanding fibrinogen geneticsBlood
The correlation between CpG methylation and gene expression is driven by sequence variantsNature Genetics

2023

Large-scale plasma proteomics comparisons through genetics and disease associationsNature
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesisNature Genetics
Actionable Genotypes and Their Association with Life Span in IcelandThe New England journal of medicine

2022

Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed programNature Communications
Genetic architecture of band neutrophil fraction in IcelandCommunications Biology
Monitoring iron stores in Icelandic blood donors from 1997 through 2019Transfusion Medicine
LærdómurLæknablaðið
Monitoring iron stores in Icelandic blood donors from 1997 through 2019Transfusion Medicine

2021

Large-scale integration of the plasma proteome with genetics and diseaseNature Genetics
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptorCommunications Biology
Genetic variants associated with platelet count are predictive of human disease and physiological markersCommunications Biology
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasisCommunications Biology
Molecular benchmarks of a SARS-CoV-2 epidemicNature Communications

2020

Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesisCommunications Biology
Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesisCommunications Biology
Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor CellsFrontiers in Cell and Developmental Biology
Context-Dependent Function of Myoepithelial Cells in Breast Morphogenesis and NeoplasiaCurrent molecular biology reports

2019

A MUC5B polymorphism associated with Idiopathic Pulmonary Fibrosis mediates overexpression through decreased CpG methylation and C/EBPβ transcriptional activation
MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasinMechanisms of Development
Ópíóíðaeitrun í kjölfar vórikónazólmeðferðar - sjúkratilfelliLæknablaðið
MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasinMechanisms of Development
Nóbelsverðlaun í læknisfræði 2019 – Súrefnisskynjun frumunnarLaeknabladid

2018

Views of Icelandic women towards genetic counseling - and testing of BRCA2 mutationsLaeknabladid
Viðhorf íslenskra kvenna til erfðaráðgjafar og erfðaprófa á BRCA1 og BRCA2 stökkbreytingumLæknablaðið
A truncating mutation in EPOR leads to hypo-responsiveness to erythropoietin with normal haemoglobinCommunications Biology

2017

Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cellsCell Death and Disease
Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cellsCell Death and Disease
Reduced anticoagulation variability in patients on warfarin monitored with Fiix-prothrombin time associates with reduced thromboembolismJournal of Thrombosis and Thrombolysis

2016

Macrophage and dendritic cell subsets in IBDMucosal Immunology
Lyfjameðferð
Læknaskóli í 140 árLaeknabladid

2015

MicroRNA-200c-141 and δNp63 are required for breast epithelial differentiation and branching morphogenesisDevelopmental Biology
KIT and PDGFRA mutations and the risk of GI stromal tumor recurrenceJournal of Clinical Oncology
Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in cultureLaboratory Investigation
HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFROncogene
Recurrent tumor growth in the right maxilla--a rare case of an inflammatory myofibroblastic tumorLæknablaðið
Nýting erfdafrædi í heilbrigdispjónustuLaeknabladid
Clinical phenotype in heterozygote and biallelic Bernard-Soulier syndrome-A case control studyAmerican Journal of Hematology
Fiix-prothrombin time versus standard prothrombin time for monitoring of warfarin anticoagulationThe Lancet Haematology
Nýting erfðafræði í heilbrigðisþjónustuLæknablaðið
Sjaldgæft tilfelli af vöðvabandvefsæxli með bólgufrumuíferð í hægri kinnkjálkaLæknablaðið

2014

Monitoring Warfarin with the Fiix-Prothrombin Time Improves Anticoagulation Stability and Long-Term Clinical Outcome. the Fiix-TrialBlood
DeltaNp63 has a role in maintaining epithelial integrity in airway epitheliumPLoS ONE
Functional role of the microrna-200 family in breast morphogenesis and NeoplasiaGenes

2013

Endothelial-rich microenvironment supports growth and branching morphogenesis of prostate epithelial cellsProstate
Importance of the efficiency of double-stranded DNA formation in cDNA synthesis for the imprecision of microarray expression analysisClinical Chemistry
Fjárfesting í ekkingu er fjárfesting til framtíarLaeknabladid
Expression and Functional Role of Sprouty-2 in Breast MorphogenesisPLoS ONE
Tveir læknar hlutu nóbels - Verolaunin í efnafræoi 2012Laeknabladid

2012

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolismJournal of the American College of Cardiology
Erfoabreytt matvæliLaeknabladid
Risk of recurrence of gastrointestinal stromal tumour after surgeryThe Lancet Oncology
Nóbelsverolaun í læknisfræoi 2012Laeknabladid

2011

Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary backgroundIn Vitro Cellular and Developmental Biology - Animal
Endothelial induced EMT in breast epithelial cells with stem cell propertiesPLoS ONE

2010

Endothelial cells stimulate growth of normal and cancerous breast epithelial cells in 3D cultureBMC Research Notes
Airway branching morphogenesis in three dimensional cultureRespiratory Research
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysmNature Genetics
Tyrosine kinase mutations in gastrointestinal stromal tumors in a nation-wide study in IcelandAPMIS
Lung Epithelial Stem Cells

2009

Design and analysis of microarray experiments for pharmacogenomics

2007

Statistically designing microarrays and microarray experiments to enhance sensitivity and specificityBriefings in Bioinformatics
Clinical study on gastrointestinal stromal tumors (GIST) in Iceland, 1990-2003Digestive Diseases and Sciences

2005

Stem cell biology and the cellular pathways of carcinogenesisAPMIS
Gastrointestinal stromal tumors in Iceland, 1990-2003International Journal of Cancer
The advent of the first generalpurpose computer in Iceland
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent mannerBlood

2003

Gene expression analysis in mastocytosis reveals a highly consistent profile with candidate molecular markersJournal of Allergy and Clinical Immunology

2002

Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor β receptor fusion oncogeneBlood

2001

Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphateProstaglandins and Other Lipid Mediators
Rabaptin-5 is a novel fusion partner to platelet-derived growth factor b receptor (PDGFbR) in chronic myelomonocytic leukemia.Blood
Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemiaBlood

1999

Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathwayBlood

1998

FibronectinArteriosclerosis, Thrombosis, and Vascular Biology
Fibronectin matrix: cellular regulations.

1997

Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contractionMolecular Biology of the Cell

1995

Iron metabolism and coronary heart disease.Primary Cardiology.

1994

Low iron-binding capacityCirculation
Low iron-binding capacity as a risk factor for myocardial infarctionCirculation

1991

Different mechanisms of homologous and heterologous desensitization of thrombin-induced endothelial prostacyclin productionEuropean Journal of Pharmacology: Molecular Pharmacology

1989

Endothelial inositol phosphate generation and prostacyclin production in response to G-protein activation by AIF₄^-Biochemical Journal

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Vísindasjóði LSH og Vísindasjóði Norrænu Ráðherranefndarinnar