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Francois Olivier Mohan Singh - Lektor

Francois Olivier Mohan Singh

–

Heilbrigðisvísindasvið

Francois Olivier Mohan Singh

Lektor

Aðsetur
Læknagarður / Lg-503
Tölvupóstur
francois [hjá] hi.is

Starfseining
Læknadeild, Lífeðlisfræðistofnun

ORCID vefsíða
https://orcid.org/0000-0002-1696-9815
Rannsóknagátt – Francois Olivier Mohan Singh

Útgefið efni

2024

Proteomic and functional comparison between human induced and embryonic stem cellseLife
PINK1 regulated mitophagy is evident in skeletal musclesAutophagy Reports

2022

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2Journal of the American Chemical Society
Physiological functions of mitophagyCurrent Opinion in Physiology

2021

Parkinson's disease and mitophagy: an emerging role for LRRK2Biochemical Society Transactions
Impact of Type II LRRK2 inhibitors on signaling and mitophagyThe Biochemical journal
Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α OverexpressionInternational Journal of Molecular Sciences
Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in miceeLife
IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytesNature Communications
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1Science advances

2020

Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced MyotoxicityEuropean cardiology
Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle ExpressionBiomedicines
Semi-automated quantitation of macroautophagy with the auto-QC counter v1
Mechanisms of statin-associated skeletal muscle-associated symptomsPharmacological Research

2019

PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in miceActa physiologica (Oxford, England)
Semi-automated quantitation of mitophagy in cells and tissuesMechanisms of Ageing and Development

2018

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic DemandCell Metabolism
PGC-1β modulates statin-associated myotoxicity in miceArchives of Toxicology
Phosphorylation of Parkin at serine 65 is essential for its activation in vivoOpen Biology

2017

Comparative analysis of resuscitation using human serum albumin and crystalloids or 130/0.4 hydroxyethyl starch and crystalloids on skeletal muscle metabolic profile during experimental haemorrhagic shock in swine: A randomised experimental studyEuropean journal of anaesthesiology
Moderate Exercise Allows for shorter Recovery Time in Critical Limb IschemiaFrontiers in Physiology
IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositisActa Neuropathologica

2016

Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncouplingHypertension research : official journal of the Japanese Society of Hypertension
Cardiac mitochondrial oxidative capacity is partly preserved after cryopreservation with dimethyl sulfoxideCryo letters
Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal MuscleAntioxidants & redox signaling
Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine DeficiencyFrontiers in Physiology

2015

Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusionAmerican Journal of Physiology - Heart and Circulatory Physiology
High reactive oxygen species in fibrotic and nonfibrotic skin of patients with diffuse cutaneous systemic sclerosisFree radical biology & medicine
Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesisBiochimica et biophysica acta
Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related strokeBioMed Research International
Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiencyAmerican journal of physiology. Endocrinology and metabolism
A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathologyEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2014

Cryopreservation with dimethyl sulfoxide prevents accurate analysis of skinned skeletal muscle fibers mitochondrial respirationBiochimie
Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptationsJournal of applied physiology (Bethesda, Md. : 1985)
Mitochondria: mitochondrial participation in ischemia-reperfusion injury in skeletal muscleThe international journal of biochemistry & cell biology

2013

Avian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageingFrontiers in Zoology

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