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Engilbert Sigurðsson - Prófessor

Engilbert Sigurðsson

–

Heilbrigðisvísindasvið

Engilbert Sigurðsson

Prófessor

Prófessor í geðlæknisfræði og yfirlæknir á LSH

Aðsetur
LSH - Hringbraut
Sími
8245345
Tölvupóstur
es [hjá] hi.is

Starfseining
Læknadeild

ORCID vefsíða
https://orcid.org/0000-0001-9404-7982
Rannsóknagátt – Engilbert Sigurðsson

Útgefið efni

2025

Genomics yields biological and phenotypic insights into bipolar disorderNature
Litíum eykur jafnvægi og lífsvilja en meðferðin krefst eftirlitsLæknablaðið
Rare loss-of-function variants in HECTD2 and AKAP11 confer risk of bipolar disorderNature Genetics
Risk of hospitalisation for first-onset psychosis or mania within a year of ADHD medication initiation in adults with ADHDBMJ Mental Health
Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapiesCell

2023

Adverse childhood experiences and psychological functioning among women with schizophrenia or bipolar disorderBritish journal of psychiatry : the journal of mental science
Geðrof í kjölfar ADHD-lyfjameðferðarLæknablaðið
Hugvíkkandi efni og meðhöndlun geðraskana á ÍslandiLæknablaðið
Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control studyCommunications Medicine
Polygenic risk predictionAmerican Journal of Human Genetics
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophreniaiScience

2024

Árangur segulörvunarmeðferðar við meðferðarþráu eða langvinnu þunglyndi í klínísku þýðiLæknablaðið
Distinct genetic liability profiles define clinically relevant patient strata across common diseasesNature Communications
Hátt algengi ADHD-lyfjameðferðar bendir til að ADHD sé ofgreint á ÍslandiLæknablaðið
MDMA sem liður í meðferð áfallastreituröskunarLæknablaðið
Persistent physical symptoms and mental health problems among individuals seeking work rehabilitationNordic Psychology
Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank studyNeuropsychopharmacology
Prevalence of Life Stressors and Posttraumatic Stress Disorder Among Women in IcelandJAMA network open
Risk of chronic kidney disease in individuals on lithium therapy in IcelandThe Lancet Psychiatry

2022

Mapping genomic loci implicates genes and synaptic biology in schizophreniaNature
Notkun psilocybins við meðferðarþráu þunglyndiLæknablaðið
Symptoms, physical measures and cognitive tests after SARS-CoV-2 infection in a large population-based case-control study
Thirty novel sequence variants impacting human intracranial volumeBrain Communications

2021

Case ReportFrontiers in Psychiatry
Evaluation of mechanism of change in transdiagnostic cognitive behaviour therapy using single case experimental designJournal of Behavior Therapy and Experimental Psychiatry
Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophreniaIntelligence
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biologyNature Genetics
HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestryTranslational Psychiatry
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.Biological Psychiatry
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With DepressionBiological psychiatry.
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK BiobankMolecular Psychiatry
Trail Making Test, Stroop, and Verbal FluencyArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

2020

Árangur ADHD-lyfjameðferðar fullorðinna í ADHD-teymi Landspítala 2015-2017Læknablaðið
Complement genes contribute sex-biased vulnerability in diverse disordersNature
Integrative cognitive remediation for early psychosisPsychiatry Research
Nýjungar og áskoranir í læknanámi á tímum rafrænna stökkbreytingaLæknablaðið
Schizophrenia, cognition, and agingAging, Neuropsychology, and Cognition
Should Patients' Values Be Discussed in Relation to Long-Term Blood Monitoring Before and During Clozapine Treatment?Journal of Clinical Psychopharmacology
Use of serotonin reuptake inhibitors is not associated with increased bleeding after CABGGeneral Thoracic and Cardiovascular Surgery
‘You should always look at the washing machine without actually being in it!’ Thematic framework analysis of patients’ understanding of transdiagnostic cognitive behaviour therapy and its mechanismsPsychology and Psychotherapy: Theory, Research and Practice
Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK BiobankBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric DisordersCell
Hæðarveiki og tengdir sjúkdómarLæknablaðið

2019

A polygenic resilience score moderates the genetic risk for schizophreniaMolecular Psychiatry
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorderTranslational Psychiatry
Ávísanir á þunglyndislyf, róandi lyf og svefnlyf hjá ungu fólki fyrir og eftir bankahrunLaeknabladid
Cognitive measures and performance on the antisaccade eye movement taskJournal of Cognition
Domestic violence-are we up to the task?Scandinavian Journal of Primary Health Care
Gene expression imputation across multiple brain regions provides insights into schizophrenia riskNature Genetics
Genome-wide association study identifies 30 loci associated with bipolar disorderNature Genetics
HLA-DQB1 6672G> C INFLUENCES THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS IN INDIVIDUALS OF EUROPEAN ANCESTRYEuropean Neuropsychopharmacology
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-bornsNature Communications
Integrative cognitive remediation for early psychosisPsychiatry Research
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophreniaAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Publisher CorrectionNature Genetics
Social and non-social measures of cognition for predicting self-reported and informant-reported functional outcomes in early psychosisScandinavian Journal of Psychology
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressionNature Genetics
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 SubphenotypesCell

1993

Identification of common genetic risk variants for autism spectrum disorderNature Genetics

2018

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed frameworkBMC Genomics
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorderCommunications Biology
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selectionNature Genetics
Constipation, ileus and medication use during clozapine treatment in patients with schizophrenia in IcelandNordic Journal of Psychiatry
Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics ConsortiumBiological Psychiatry
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum LikelihoodAmerican Journal of Human Genetics
Improving genetic prediction by leveraging genetic correlations among human diseases and traitsNature Communications

2017

15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculiaTranslational Psychiatry
General Practice - new challenges with classical core[Editorial]Laeknabladid
Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulationsJAMA Psychiatry
Genetic correlation between amyotrophic lateral sclerosis and schizophreniaNature Communications
Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar DisorderBiological Psychiatry
Genome-wide Association for Major Depression Through Age at Onset StratificationBiological Psychiatry
Hair Cortisol in TwinsScientific Reports
Methylphenidate disintegration from oral formulations for intravenous use by experienced substance usersDrug and Alcohol Dependence
Polygenic risk scores for schizophrenia and bipolar disorder associate with addictionAddiction Biology
Reproductive fitness and genetic risk of psychiatric disorders in the general populationNature Communications
Risk of diabetes and dyslipidemia during clozapine and other antipsychotic drug treatment of schizophrenia in IcelandNordic Journal of Psychiatry
Truncating mutations in RBM12 are associated with psychosisNature Genetics

2016

Clozapine treatment and discontinuation in IcelandNordic Journal of Psychiatry
Intravenous Use of Prescription Psychostimulants; A Comparison of the Pattern and Subjective Experience between Different Methylphenidate Preparations, Amphetamine and CocaineEuropean Addiction Research
KaflaskilLaeknabladid
Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in IcelandBMC Psychiatry
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication StudyPLoS Genetics
Transdiagnostic cognitive behavioural treatment and the impact of co-morbidityNordic Journal of Psychiatry
Þunglyndi og kransæðasjúkdómar

2015

Ad höggva undan sér fæturnaLaeknabladid
Bugging bugsScandinavian Journal of Primary Health Care
Evaluation of the Psychometric Properties of the Icelandic Version of the Clinical Outcomes in Routine Evaluation-Outcome Measure, its Transdiagnostic Utility and Cross-Cultural ValidationClinical Psychology and Psychotherapy
LD score regression distinguishes confounding from polygenicity in genome-wide association studiesNature Genetics
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk ScoresAmerican Journal of Human Genetics
Polygenic risk scores for schizophrenia and bipolar disorder predict creativityNature Neuroscience
Prevalent intravenous abuse of methylphenidate among treatment-seeking patients with substance abuse disordersJournal of Addiction Medicine
The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjectsMolecular Psychiatry

2014

Biological insights from 108 schizophrenia-associated genetic lociNature
CNVs conferring risk of autism or schizophrenia affect cognition in controlsNature
Common variant at 16p11.2 conferring risk of psychosisMolecular Psychiatry
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility geneMolecular Psychiatry
Does the use of cannabis increase the risk for psychosis and the development of schizophrenia?Læknablaðið
EmetophobiaLaeknabladid
Eykur notkun kannabis hættu á gedrofi og próun gedklofa?Laeknabladid
Identification of pathways for bipolar disorderJAMA Psychiatry
Læknablaðið 100 áraLæknablaðið
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseasesAmerican Journal of Human Genetics
Variability inworking memory performance explained by epistasis vs polygenic scores in the ZNF804A pathwayJAMA Psychiatry

2013

Áhrif þunglyndislyfja og róandi lyfja á árangur af ósértækri hugrænni atferlismeðferð hópa í heilsugæsluLaeknabladid
A mega-Analysis of genome-wide association studies for major depressive disorderMolecular Psychiatry
Genome-wide association analysis identifies 13 new risk loci for schizophreniaNature Genetics
Hserra á neydarástandi á landspítala.Læknabladid
Opening Pandora's box in the UKPharmacogenomics
Schizophrenia genetic variants are not associated with intelligencePsychological Medicine

2012

Association study of nonsynonymous single nucleotide polymorphisms in schizophreniaBiological Psychiatry
Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorderBiological Psychiatry
Response to Boot et al. letterAmerican Journal of Psychiatry
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locusNature

2011

Aftur til fortíðarLæknablaðið
At-risk variant in TCF7L2 for type II diabetes increases risk of schizophreniaBiological Psychiatry
Back to the past. Case report and review on retrograde memory lossLæknablaðið
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophreniaBiological Psychiatry
Common variants at VRK2 and TCF4 conferring risk of schizophreniaHuman Molecular Genetics
Common variants on 8p12 and 1q24.2 confer risk of schizophreniaNature Genetics
Copy number variations of chromosome 16p13.1 region associated with schizophreniaMolecular Psychiatry
Developments in schizophrenia geneticsNordic Journal of Psychiatry
Eðli manna og þróun fræðitímaritaLæknablaðið
Efficacy of cognitive behavioral therapy in the treatment of mood and anxiety disorders in adultsLæknablaðið
Expanding the range of ZNF804A variants conferring risk of psychosisMolecular Psychiatry
Gagnsemi hugrænnar atferlismeðferðar við lyndis- og kvíðaröskunum hjá fullorðnumLæknablaðið
Genome-wide association study identifies five new schizophrenia loci.Nature Genetics
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorderAmerican Journal of Human Genetics
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder (The American Journal of Human Genetics (2011) 88, (372-381))American Journal of Human Genetics
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.Nature Genetics
Maternally derived microduplications at 15q11-q13American Journal of Psychiatry

2010

Catechol-o-methyltransferase val¹⁵⁸met polymorphism and antisaccade eye movements in schizophreniaSchizophrenia Bulletin
FíFL vakna úr vetrardvalaLaeknabladid
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohortJournal of Psychiatric Research
Hlutverk lækna í hagræðingu innan heilbrigðiskerfisinsLaeknabladid
Neuregulin-1 genotypes and eye movements in schizophreniaEuropean Archives of Psychiatry and Clinical Neuroscience
S100B profiles and cognitive function at high altitudeHigh Altitude Medicine and Biology

2009

Common variants conferring risk of schizophreniaNature
COMT val¹⁵⁸met genotype and smooth pursuit eye movements in schizophreniaPsychiatry Research
Disruption of the neurexin 1 gene is associated with schizophreniaHuman Molecular Genetics
Enginn veit hvad átt hefur fyrr en misst hefurLaeknabladid
FÍFLagangur ad voriLaeknabladid
Hver eru viðhorf Íslendinga til þunglyndislyfja og hvað mótar viðhorfin?Læknablaðið
Hverjir skrifa í Læknablaðið ? Yfirlit yfir fræðigreinar síðustu fimm ára.Laeknabladid

2008

Eye movement deficits in schizophreniaEuropean Archives of Psychiatry and Clinical Neuroscience
Large recurrent microdeletions associated with schizophreniaNature
Misskipt er manna lániLæknablaðið
Munur á meðferðarárangri einstaklinga með þunglyndi og kvíðatengt þunglyndiSálfræðiritið
Public views on antidepressant treatmentNordic Journal of Psychiatry
Vacuum-assisted closure for successful treatment of a major contaminated gunshot chest-woundEuropean Journal of Trauma and Emergency Surgery

2007

Support for involvement of the AHI1 locus in schizophreniaEuropean Journal of Human Genetics

2006

Geðsjúkdómar í fjölmiðlumLæknablaðið
Health-related quality of life of patients with implantable cardioverter defibrillators compared with that of pacemaker recipientsEuropace

2004

Genes for schizophrenia can be detected at least in Iceland.
Genomics and genealogy provide an Icelandic springboard into the human gene poolJournal of Mental Health

2003

Geðklofagen, gereyðingarvopn og geðlæknaþingLæknablaðið

2002

Are impaired childhood motor skills a risk factor for adolescent anxiety? Results from the 1958 U.K. birth cohort and the National Child Development StudyAmerican Journal of Psychiatry
Neuregulin 1 and Susceptibility to SchizophreniaAmerican Journal of Human Genetics

1999

Neurodevelopmental antecedents of early-onset bipolar affective disorderBritish Journal of Psychiatry
Neurodevelopmental delay in the severely ill [8] (multiple letters)British Journal of Psychiatry

1994

The effects of electroconvulsive therapy and depression on confabulation, memory processing, and suggestibilityNordic Journal of Psychiatry
Value of antibodies to GAD₆₅ combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood populationDiabetologia

1990

The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitusCurrent Topics in Microbiology and Immunology

1989

The beta cell autoantigens-which ones may be relevant?

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Erfðafræði geðrofssjúkdóma-eintakabreytileiki og sjúkdómar í miðtaugakerfi-geðhvarfasjúkdómur-aukaverkanir tengdar geðrofslyfjameðferð og litíum