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Bárður Sigurgeirsson - Prófessor

Bárður Sigurgeirsson

–

Heilbrigðisvísindasvið

Bárður Sigurgeirsson

Prófessor

Húðlæknir

Sími
5204444
Tölvupóstur
bsig [hjá] hi.is

Starfseining
Læknadeild
Vefsíða
http://www.hls.is

ORCID vefsíða
https://orcid.org/0000-0002-9733-9742
Rannsóknagátt – Bárður Sigurgeirsson

Útgefið efni

2024

Gene-based burden tests of rare germline variants identify six cancer susceptibility genesNature Genetics

2023

Position statementJournal of the European Academy of Dermatology and Venereology
Data from Loss-of-Function Variants in the Tumor-Suppressor Gene <i>PTPN14</i> Confer Increased Cancer Risk
Secukinumab long-term efficacy and safety in psoriasis through to year 5 of treatmentBritish Journal of Dermatology

2021

Loss-of-function variants in the tumor-suppressor gene PTPN14 confer increased cancer riskCancer Research
Emerging antifungal treatment failure of dermatophytosis in EuropeJournal of the European Academy of Dermatology and Venereology
Efficacy, tolerability, patient usability, and satisfaction with a 2 mL pre-filled syringe containing secukinumab 300 mg in patients with moderate to severe plaque psoriasisJournal of Dermatological Treatment
Secukinumab demonstrates efficacy, safety, and tolerability upon administration by 2 ml autoinjector in adult patients with plaque psoriasisDermatologic Therapy
Keratinocytes secrete multiple inflammatory and immune biomarkers, which are regulated by LL-37, in a psoriasis mimicking microenvironmentScandinavian Journal of Immunology

2020

FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid diseaseNature
Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patientsBritish Journal of Clinical Pharmacology
Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinomaNature Communications

2019

A survey among dermatologistsJournal of the European Academy of Dermatology and Venereology
Effective treatment with balneophototherapy and narrowband UVB monotherapy reduces skin homing Th17/Tc17 and Th22/Tc22 effector cells in peripheral blood in patients with psoriasisJournal of Dermatological Science

2018

Predicting the outcome of treatment
Systemic therapy of onychomycosis
Association of brca2 k3326∗ with small cell lung cancer and squamous cell cancer of the skinJournal of the National Cancer Institute

2017

A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitisBritish Journal of Dermatology
Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled TrialActa Dermato Venereologica
Patient-reported Outcomes and Clinical Response in Patients with Moderate-tosevere Plaque Psoriasis Treated with TonsillectomyActa Dermato-Venereologica
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlationsnpj Genomic Medicine
Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosisMycoses
Secukinumab re-initiation achieves regain of high response levels in patients who interrupt treatment for moderate to severe plaque psoriasisBritish Journal of Dermatology

2016

HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomyJournal of the American Academy of Dermatology
Onychomycosis
The Antifungal Drugs Used in Skin Disease
Secukinumab improves patient-reported psoriasis symptoms of itching, pain, and scalingInternational Journal of Dermatology
Throat infections are associated with exacerbation in a substantial proportion of patients with chronic plaque psoriasisActa Dermato-Venereologica
Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal subungual toenail onychomycosisMycoses

2015

Cutaneous melanoma in IcelandJournal of the European Academy of Dermatology and Venereology
Safety and efficacy of pimecrolimus in atopic dermatitisPediatrics
New basal cell carcinoma susceptibility lociNature Communications
Secukinumab improves physical function in subjects with plaque psoriasis and psoriatic arthritisJournal of Drugs in Dermatology

2014

Psoriasis treatmentPhotodermatology Photoimmunology and Photomedicine
Secukinumab improves the signs and symptoms of moderate-to-severe plaque psoriasis in subjects with involvement of hands and/or feetJournal of the European Academy of Dermatology and Venereology
Psoriatic nail disease, a predictor of psoriatic arthritisBritish Journal of Dermatology
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinomaHuman Molecular Genetics
Secukinumab in plaque psoriasis - Results of two phase 3 trialsNew England Journal of Medicine
The prevalence of onychomycosis in the global population – A literature studyJournal of the European Academy of Dermatology and Venereology

2013

Efficacy, safety and tolerability of topical terbinafine nail solution in patients with mild-to-moderate toenail onychomycosisJournal of the European Academy of Dermatology and Venereology
Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasisBritish Journal of Dermatology
Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasisBritish Journal of Dermatology
The Role of Th17/Tc17 Peripheral Blood T cells in Psoriasis and Their Positive Therapeutic ResponseScandinavian Journal of Immunology
A phase II, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to investigate the efficacy and safety of 4 dose regimens of oral albaconazole in patients with distal subungual onychomycosisJournal of the American Academy of Dermatology
A variant in FTO shows association with melanoma risk not due to BMINature Genetics

2012

Therapeutic potential of TDT 067 (terbinafine in Transfersome®)Expert Opinion on Investigational Drugs
Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinantsJournal of Immunology

2011

Mælingar á rooavaldandi geislum sólarinnar sumario 2010Laeknabladid
Rooavaldandi geislar sólarinnar og phorn;ýoing phorn;eirraLaeknabladid
The zebrafish brain in research and teachingAmerican Journal of Physiology - Advances in Physiology Education
A germline variant in the TP53 polyadenylation signal confers cancer susceptibilityNature Genetics
Erythemogenic UV raysLæknablaðið

2010

UV-index in Iceland during the summer of 2010Læknablaðið
A melanoma epidemic in icelandAmerican Journal of Epidemiology
Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 yearsJournal of the European Academy of Dermatology and Venereology
Autier et al. Respond to "a sunbed epidemic?"American Journal of Epidemiology
Prognostic factors for cure following treatment of onychomycosisJournal of the European Academy of Dermatology and Venereology

2009

Parental origin of sequence variants associated with complex diseasesNature
Sequence variants at the TERT-CLPTM1L locus associate with many cancer typesNature Genetics
New common variants affecting susceptibility to basal cell carcinomaNature Genetics

2008

ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinomaNature Genetics
Two newly identified genetic determinants of pigmentation in EuropeansNature Genetics
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traitsNature Genetics
Effectiveness and safety of a prevention-of-flare-progression strategy with pimecrolimus cream 1% in the management of paediatric atopic dermatitisJournal of the European Academy of Dermatology and Venereology
CDKN2A mutations and melanoma risk in the Icelandic populationJournal of Medical Genetics
CorrigendumNature Genetics

2007

Genetic determinants of hair, eye and skin pigmentation in EuropeansNature Genetics
A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvementBritish Journal of Dermatology
OnychomycosisJournal of the American Academy of Dermatology

2006

Onychomycosis in Icelandic childrenJournal of the European Academy of Dermatology and Venereology
Intermittent versus continuous terbinafine in the treatment of toenail onychomycosisJournal of Dermatological Treatment

2005

Lifestyle of Nordic people with psoriasisInternational Journal of Dermatology
Dermatophytes in a swimming pool facilityActa Dermato-Venereologica

2004

The darker side of tanningLæknablaðið
Chronic dermatomycoses of the foot as risk factors for acute bacterial cellulitis of the legDermatology
Blessuð sólin elskar allt [ritstjórnargrein]Læknablaðið
Self-reported stress reactivity and psoriasis-related stress of Nordic psoriasis sufferersJournal of the European Academy of Dermatology and Venereology
Risk factors associated with onychomycosisJournal of the European Academy of Dermatology and Venereology
Risk factors for malignant melanoma in an Icelandic population samplePreventive Medicine

2003

Risk factors for cutaneous malignant melanoma among aircrews and a random sample of the populationOccupational and Environmental Medicine
Combination therapy for onychomycosisBritish Journal of Dermatology, Supplement
Streptococcal throat infections and exacerbation of chronic plaque psoriasisBritish Journal of Dermatology

2002

Long-term effectiveness of treatment with terbinafine vs itraconazole in onychomycosisArchives of Dermatology
Quality of life in 6497 Nordic patients with psoriasisBritish Journal of Dermatology
Prognostic factors of mycological cure following treatment of onychomycosis with oral antifungal agentsBritish Journal of Dermatology
Prevalence of onychomycosis in IcelandActa Dermato-Venereologica
Quality of life and prevalence of arthritis reported by 5,795 members of the Nordic Psoriasis Associations. Data from the Nordic quality of life studyActa Dermato-Venereologica

2001

Treatment of psoriasis in the nordic countriesActa Dermato-Venereologica
Frequency of specific cancer types in dermatomyositis and polymyositisLancet
Dermatomycoses in Iceland 1982-2000

2000

Incidence of skin cancer in 5356 patients following organ transplantationBritish Journal of Dermatology

1999

PUVA and cancer riskBritish Journal of Dermatology
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasisBritish Journal of Dermatology
Onychomycosis in icelandic swimmersActa Dermato-Venereologica
Double blind randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosisBritish Medical Journal
L.I.ON. StudyBritish Journal of Dermatology, Supplement
Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?Clinical and Experimental Immunology

1998

Melanocytic naevus or malignant melanoma? A large-scale epidemiological study of diagnostic accuracyActa Dermato-Venereologica
On the association between vitiligo and malignant melanoma [11]Acta Dermato-Venereologica

1997

Circulating T cells of patients with active psoriasis respond to streptococcal M-Peptides sharing sequences with human epidermal keratinsScandinavian Journal of Immunology
What is the long term value of multiphasic health screening and the initial judgement of benefit?Scandinavian Journal of Social Medicine, Supplement
What is the long term value of multiphasic health screening and the initial judgement of benefit? Survival to 85 and 90 years, perceived health and functional ability of participants in the Swedish Eskilstuna study 1964 and 1969, 20 and 25 years laterScandinavian Journal of Social Medicine, Supplement

1996

Psoriasis treatmentActa Dermato-Venereologica

1995

Venous leg ulcers and squamous cell carcinomaBritish Journal of Dermatology

1994

The effect bathing in a thermal lagoon in Iceland has on psoriasis. A preliminary studyJournal of the European Academy of Dermatology and Venereology
Risk of lymphoma in patients with dermatitis herpetiformisThe BMJ
Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infantsPediatric Allergy and Immunology

1993

PUVA and cancerBritish Journal of Dermatology
Leg ulcers and squamous cell carcinoma. An epidemiological study and a review of the literatureActa Dermato-Venereologica
Psoralen Photochemotherapy (PUVA) and PregnancyArchives of Dermatology

1992

Condylomata acuminata and risk of cancerObstetrical and Gynecological Survey
Skin disease and malignancyActa Dermato-Venereologica, Supplement
Risk of Cancer in Dermatomyositis or PolymyositisNew England Journal of Medicine
Seborrheic keratoses and cancerJournal of the American Academy of Dermatology
Comparison of the Carcinogenic Potential of Trioxsalen Bath PUVA and Oral Methoxsalen PUVAArchives of Dermatology

1991

CANESTComputer Methods and Programs in Biomedicine
PUVA treatment in SwedenActa Dermato-Venereologica, Supplement
Condylomata acuminata and risk of cancer [4]British Medical Journal
Lichen Planus and MalignancyArchives of Dermatology
Occurrence of other malignancies in 1973 patients with basal cell carcinomaJournal of the American Academy of Dermatology
PUVA and cancerThe Lancet
Condylomata acuminata and risk of cancerBritish Medical Journal

1990

Chronic urticaria and cancerBritish Journal of Dermatology

1985

Acute Thoracic Inlet Obstruction in Achalasia with Adenoid Cystic and Squamous Cell CarcinomaAnnals of Thoracic Surgery

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