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Forsíða

Francois Olivier Mohan Singh - Assistant Professor

Francois Olivier Mohan Singh

–

School of Health Sciences

Francois Olivier Mohan Singh

Assistant Professor

Location
Læknagarður / Lg-503
Phone
525 - 4859
Email
francois [at] hi.is

Unit
Biochemistry

Published works

2025

Joint 2025 Autophagy and Proteostasis UK conferenceJoint 2025 Autophagy and Proteostasis UK conference
Editorial: The contribution of autophagy to neuronal metabolismFrontiers in Cell and Developmental Biology

2024

Frontiers in Cell and Developmental Biology (Fræðitímarit)
Proteomic and functional comparison between human induced and embryonic stem cellseLife
Biomedical Center (Utanaðkomandi stofnun)
Nordic Autophagy Society (Utanaðkomandi stofnun)
7th Nordic Autophagy Society Conference7th Nordic Autophagy Society Conference
PINK1 regulated mitophagy is evident in skeletal musclesAutophagy Reports

2022

Physiological functions of mitophagyCurrent Opinion in Physiology
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2Journal of the American Chemical Society

2021

IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytesNature Communications
Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in miceeLife
Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α OverexpressionInternational Journal of Molecular Sciences
Parkinson's disease and mitophagy: an emerging role for LRRK2Biochemical Society Transactions
Impact of Type II LRRK2 inhibitors on signaling and mitophagyThe Biochemical journal
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1Science advances

2020

Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced MyotoxicityEuropean cardiology
Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle ExpressionBiomedicines
Semi-automated quantitation of macroautophagy with the auto-QC counter v1
Mechanisms of statin-associated skeletal muscle-associated symptomsPharmacological Research

2019

Semi-automated quantitation of mitophagy in cells and tissuesMechanisms of Ageing and Development
PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in miceActa physiologica (Oxford, England)

2018

PGC-1β modulates statin-associated myotoxicity in miceArchives of Toxicology
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic DemandCell Metabolism
Phosphorylation of Parkin at serine 65 is essential for its activation in vivoOpen Biology

2017

IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositisActa Neuropathologica
Comparative analysis of resuscitation using human serum albumin and crystalloids or 130/0.4 hydroxyethyl starch and crystalloids on skeletal muscle metabolic profile during experimental haemorrhagic shock in swine: A randomised experimental studyEuropean journal of anaesthesiology
Moderate Exercise Allows for shorter Recovery Time in Critical Limb IschemiaFrontiers in Physiology

2016

Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncouplingHypertension research : official journal of the Japanese Society of Hypertension
Cardiac mitochondrial oxidative capacity is partly preserved after cryopreservation with dimethyl sulfoxideCryo letters
Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal MuscleAntioxidants & redox signaling
Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine DeficiencyFrontiers in Physiology

2015

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesisBiochimica et biophysica acta
Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusionAmerican Journal of Physiology - Heart and Circulatory Physiology
A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathologyEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiencyAmerican journal of physiology. Endocrinology and metabolism
Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related strokeBioMed Research International
High reactive oxygen species in fibrotic and nonfibrotic skin of patients with diffuse cutaneous systemic sclerosisFree radical biology & medicine

2014

Cryopreservation with dimethyl sulfoxide prevents accurate analysis of skinned skeletal muscle fibers mitochondrial respirationBiochimie
Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptationsJournal of applied physiology (Bethesda, Md. : 1985)
Mitochondria: mitochondrial participation in ischemia-reperfusion injury in skeletal muscleThe international journal of biochemistry & cell biology

2013

Avian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageingFrontiers in Zoology

Keywords for Specialisation:

Mitochondrial biogenesis

Skeletal muscle

Parkinson's disease

Reactive oxygen species