Skip to main content

EN
ÍS

Forsíða

Forsíða

Þórarinn Guðjónsson - Professor

Þórarinn Guðjónsson

–

School of Health Sciences

Þórarinn Guðjónsson

Professor

Professor in histology

Location
Læknagarður / Lg-416
Phone
525 - 4827 8615695
Email
tgudjons [at] hi.is

Unit
Biochemistry
Website
http://www.lifvisindi.hi.is/thorarinn_gudjonsson

Published works

2026

2,8-Dihydroxyadenine disrupts epithelial integrity and alters kidney cell phenotype in vitroJournal of Molecular Medicine

2025

Breast MorphogenesisAdvances in Experimental Medicine and Biology
A novel macrolide, EP395, with reduced antibacterial activity and an enhancing effect on respiratory epithelial barrierPulmonary Pharmacology and Therapeutics
The Non-Antibacterial Effects of Azithromycin and Other Macrolides on the Bronchial Epithelial Barrier and Cellular DifferentiationInternational Journal of Molecular Sciences

2024

Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity
The influence of physical and spatial substrate characteristics on endothelial cellsMaterials Today Bio
Fjölgun læknanema við læknadeild Háskóla ÍslandsLæknablaðið

2023

Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypesFrontiers in Oncology
Prospects for macrolide therapy of asthma and COPD

2022

Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer InitiationCancers
An Organotypic Assay to Study Epithelial-Fibroblast Interactions in Human Breast
Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse modelLaboratory Animal Research
Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative StressMolecular and Cellular Proteomics
Application of 3D Culture Assays to Study Breast Morphogenesis, Epithelial Plasticity, and Cellular Interactions in an Epithelial Progenitor Cell Line

2021

Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screenMolecular Oncology
Ventilator-induced lung-injury in mouse models: Is there a trap?Laboratory Animal Research
The Wittig bioconjugation of maleimide derived, water soluble phosphonium ylides to aldehyde-tagged proteinsOrganic and Biomolecular Chemistry
Aminopeptidase expression in multiple myeloma associates with disease progression and sensitivity to melflufenCancers
Nonantimicrobial actions of macrolidesPharmacological Reviews
Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492Journal of Mammary Gland Biology and Neoplasia
Correction toJournal of Mammary Gland Biology and Neoplasia

2020

Melflufen, a peptide‐conjugated alkylator, is an efficient anti‐neo‐plastic drug in breast cancer cell linesCancer Medicine
Azithromycin has lung barrier protective effects in a cell model mimicking ventilator-induced lung injuryAltex
Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responsesRespiratory Research
ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasionLaboratory Investigation
Context-Dependent Function of Myoepithelial Cells in Breast Morphogenesis and NeoplasiaCurrent molecular biology reports
Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor CellsFrontiers in Cell and Developmental Biology

2019

Innovative in vitro method to study ventilator induced lung injuryAltex
MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasinMechanisms of Development
YKL-40/CHI3L1 facilitates migration and invasion in HER2 overexpressing breast epithelial progenitor cells and generates a niche for capillary-like network formationIn Vitro Cellular & Developmental Biology - Animal
A MUC5B polymorphism associated with Idiopathic Pulmonary Fibrosis mediates overexpression through decreased CpG methylation and C/EBPβ transcriptional activation
Azithromycin induces epidermal differentiation and multivesicular bodies in airway epitheliaRespiratory Research
Cell Internalization in Fluidic Culture Conditions Is Improved When Microparticles Are Specifically Targeted to the Human Epidermal Growth Factor Receptor 2 (HER2)Pharmaceutics
Application of the D492 Cell Lines to Explore Breast Morphogenesis, EMT and Cancer Progression in 3D CultureJournal of Mammary Gland Biology and Neoplasia
MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasinMechanisms of Development

2017

Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cellsCell Death and Disease
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transitionCancer Letters
Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cellsCell Death and Disease

2016

Epithelial Plasticity During Human Breast Morphogenesis and Cancer ProgressionJournal of Mammary Gland Biology and Neoplasia
EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMTPLoS Computational Biology

2015

Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cellsPeerJ
Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in cultureLaboratory Investigation
Sjaldgæft tilfelli af vöðvaband-vefsæxli med bólgufrumuíferð í hægri kinnkjálkaLaeknabladid
Sjaldgæft tilfelli af vöðvabandvefsæxli með bólgufrumuíferð í hægri kinnkjálkaLæknablaðið
Curcumin, bisdemethoxycurcumin and dimethoxycurcumin complexed with cyclodextrins have structure specific effect on the paracellular integrity of lung epithelia in vitroBiochemistry and Biophysics Reports
MicroRNA-200c-141 and δNp63 are required for breast epithelial differentiation and branching morphogenesisDevelopmental Biology
Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cellsPeerJ
Recurrent tumor growth in the right maxilla--a rare case of an inflammatory myofibroblastic tumorLæknablaðið
HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFROncogene

2014

Relationship between the structure of N-alkyl-N,N-dimethyl chitosan derivatives and their permeation enhancing effect in bronchial epithelia in vitro.European Journal of Pharmaceutics and Biopharmaceutics
Functional role of the microrna-200 family in breast morphogenesis and NeoplasiaGenes
N-alkylation of highly quaternized chitosan derivatives affects the paracellular permeation enhancement in bronchial epithelia in vitroEuropean Journal of Pharmaceutics and Biopharmaceutics
Samkeppnissjódir vísinda- og tækniráds og rannsóknir í heilbrigdis- og lífvísindumLaeknabladid
DeltaNp63 has a role in maintaining epithelial integrity in airway epitheliumPLoS ONE

2013

Endothelial-rich microenvironment supports growth and branching morphogenesis of prostate epithelial cellsProstate
Lífvísindasetur Háskóla ÍslandsLaeknabladid
Expression and Functional Role of Sprouty-2 in Breast MorphogenesisPLoS ONE
Drug delivery characteristics of the progenitor bronchial epithelial cell line VA10Pharmaceutical Research

2012

Regioselective fluorescent labeling of N,N,N-trimethyl chitosan via oxime formationCarbohydrate Polymers

2011

Endothelial induced EMT in breast epithelial cells with stem cell propertiesPLoS ONE
Lung Epithelial Stem Cells
Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary backgroundIn Vitro Cellular and Developmental Biology - Animal

2010

Azithromycin maintains airway epithelial integrity during Pseudomonas aeruginosa infectionAmerican Journal of Respiratory Cell and Molecular Biology
Endothelial cells stimulate growth of normal and cancerous breast epithelial cells in 3D cultureBMC Research Notes
Lung Epithelial Stem Cells
Airway branching morphogenesis in three dimensional cultureRespiratory Research
Fabrication of planar polymer waveguides for evanescent-wave sensing in aqueous environmentsMicroelectronic Engineering

2009

Evanescent-wave fluorescence microscopy using symmetric planar waveguidesOptics Express

2008

Notkun stofnfrumna til rannsókna og læninga átaugasjú dómumLaeknabladid
Notkun stofnfrumna til rannsókna og lækninga á taugasjúkdómumLæknablaðið
Þróun nýrrar örflögutækni fyrir smásjárskoðun lífrænna sýnaRAUST - Tímarit um raunvísindi og stærðfræði

2007

Differentiation potential of a basal epithelial cell line established from human bronchial explantIn Vitro Cellular and Developmental Biology - Animal
Evidence for a stem cell hierarchy in the adult human breastJournal of Cell Biology

2006

Human breast microvascular endothelial cells retain phenotypic traits in long-term finite life span cultureIn Vitro Cellular and Developmental Biology - Animal
Novel effects of azithromycin on tight junction proteins in human airway epitheliaAntimicrobial Agents and Chemotherapy

2005

Establishment of three human breast epithelial cell lines derived from carriers of the 999del5 BRCA2 icelandic founder mutationIn Vitro Cellular and Developmental Biology - Animal
Maintenance of cell type diversification in the human breastJournal of Mammary Gland Biology and Neoplasia
Stem cellsAPMIS
Stem cell biology and the cellular pathways of carcinogenesisAPMIS
Myoepithelial cellsJournal of Mammary Gland Biology and Neoplasia

2004

Immortalization protocols used in cell culture models of human breast morphogenesisCellular and Molecular Life Sciences

2003

Characterization of a novel breast carcinoma xenograft and cell line derived from a BRCA1 germ-line mutation carrierLaboratory Investigation
Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of α-smooth muscle actin expressionIn Vitro Cellular and Developmental Biology - Animal
Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasiaCell Proliferation, Supplement
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stromaAmerican Journal of Pathology
To create the correct microenvironmentMethods
Eiginleikar stofnfrumnaLæknablaðið

2002

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane depositionJournal of Cell Science
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell propertiesGenes and Development

2001

The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversionBreast Cancer Research

1999

Human mammary luminal epithelial cells contain progenitors to myoepithelial cellsDevelopmental Biology

Keywords for Specialisation:

Stem Cell Biology

3D cell culture

Branching morphogenesis

Drug development

Epithelial barrier