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Forsíða

Forsíða

Sveinbjörn Gizurarson - Professor

Sveinbjörn Gizurarson

–

School of Health Sciences

Sveinbjörn Gizurarson

Professor

Professor

Location
Hagi
Phone
525 - 5807 8980318
Email
sveinbj [at] hi.is

Unit
Faculty of Pharmaceutical Sciences
Website
http://www.uni.hi.is/sveinbj

Published works

2024

Incompatibility of antimalarial drugsDrug Delivery
Placental Protein 13International Journal of Molecular Sciences
Compliance and illiteracy when treating tuberculosisInternational Health

2023

Pharmacological Approach to Combat Mosquito Transmitted Malaria
Colour of Medicines and Children’s Acceptability? A Systematic Literature Review of Children’s Perceptions about Colours of Oral Dosage FormsPharmaceutics
Reenterable colored Petri net model of Ebola virus dynamics
Estimation of Pediatric Dosage of Antimalarial Drugs, Using Pharmacokinetic and Physiological ApproachPharmaceutics
A Case Study: How the Rephaiah Project Combats Malaria in Young Children

2022

Adjuvants, immunomodulators, and adaptogens
Handbook for Laboratory Safety

2021

Endothelium-derived hyperpolarizing factor (Edhf) mediates acetylsalicylic acid (aspirin) vasodilation of pregnant rat mesenteric arteriesInternational Journal of Molecular Sciences
Pharmacokinetics of single and repeated oral doses of esomeprazole and gastrin elevation in healthy males and femalesScandinavian Journal of Gastroenterology
The effect of trehalose, antioxidants, and acetate buffer concentration on oxytocin stabilityJournal of Peptide Science
Path towards efficient paediatric formulation development based on partnering with clinical pharmacologists and clinicians, a conect4children expert group white paperBritish Journal of Clinical Pharmacology
Effect of 18-Crown-6 on Oxytocin Stability in Aqueous Buffer SolutionsACS Omega
Rational vaccine design in times of emerging diseasesPharmaceutics
The effect of D-(+)-glucosamine, N-acetyl-D-glucosamine and tetraethylene glycol on the stability of oxytocin in aqueous solutionDie Pharmazie
Effect of doxycycline microencapsulation on buccal filmsGels

2020

Preventing Incompatibility Among Malarial Drugs
Modulation of immune responses using adjuvants to facilitate therapeutic vaccinationImmunological Reviews
Predictors of Gastrin Elevation Following Proton Pump Inhibitor TherapyJournal of Clinical Gastroenterology
Comparability of Raman Spectroscopic ConfigurationsAnalytical Chemistry
Long-term stabilization of aqueous doxycycline formulations, in mucoadhesive hydrogels for treatment of oral mucosal conditionsCurrent Drug Discovery Technologies
Evaluation of in vitro mucoadhesiveness and texture profile analysis of doxycycline in situ hydrogelsPharmazie

2019

Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration.International Journal of Women's Health
Doxycycline and Monocaprin In Situ Hydrogel: Effect on Stability, Mucoadhesion and Texture Analysis and In Vitro ReleaseGels
Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administrationInternational Journal of Women's Health
The Protection of Oxytocin and Degradation in Aqueous Solutions using Glucosamine and Tetraethyleneglycol
Stability of thromboxane in blood samplesVascular Health and Risk Management
Galectin 13 (PP13) facilitates remodeling and structural stabilization of maternal vessels during pregnancyInternational Journal of Molecular Sciences
Aspirin causes endothelium-dependent vasodilation of resistance arteries from non-gravid and gravid ratsPregnancy Hypertension
Stability of thromboxane in blood samples.Vascular health and risk management
The Stability of Oxytocin in Aqueous Solutions with Glucosamine and Tetraethyleneglycol

2018

Aspirin Versus Placebo in Pregnancies at High Risk for Preterm PreeclampsiaObstetrical and Gynecological Survey
Evaluation of intranasal delivery route of drug administration for brain targetingBrain Research Bulletin
Pharmacokinetics of placental protein 13 after intravenous and subcutaneous administration in rabbitsDrug Design, Development and Therapy

2017

Aspirin versus Placebo in Pregnancies at High Risk for Preterm PreeclampsiaNew England Journal of Medicine
Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or FunctionComputational and Structural Biotechnology Journal
Lyfjafræðileg umsjá í Heilsugæslunni í Garðabæ - greining á fjölda og eðli lyfjatengdra vandamála eldri einstaklingaLæknablaðið
Study of Gender Differences in Proton Pump Inhibitor Dose Requirements for GERDJournal of Clinical Gastroenterology
Aspirin versus placebo in pregnancies at high risk for preterm preeclampsiaNew England Journal of Medicine
Lyfjafræoileg umsjá í Heilsugæslunni í Garoabæ - greining á fjölda og eoli lyfjatengdra vandamála eldri einstaklingaLaeknabladid
Nose-to-brain transport of imatinib mesylateEuropean Journal of Pharmaceutical Sciences
Placental protein 13 (PP13)-induced vasodilation of resistance arteries from pregnant and nonpregnant rats occurs via endothelial-signaling pathwaysHypertension in Pregnancy

2016

Perception of the Professional Knowledge of and Education on the Medical Technology Products among the Pharmacists in the Baltic and Nordic Countries—A Cross-Sectional Exploratory StudyPharmacy
Placental Protein 13 Administration to Pregnant Rats Lowers Blood Pressure and Augments Fetal Growth and Venous RemodelingFetal Diagnosis and Therapy

2015

The effect of cilia and the mucociliary clearance on successful drug deliveryBiological and Pharmaceutical Bulletin

2014

Impact of changes to reimbursement of fixed combinations of inhaled corticosteroids and long-acting β₂-agonists in obstructive lung diseasesInternational Journal of Clinical Practice
Placental Protein 13 (PP13) - A placental immunoregulatory galectin protecting pregnancyFrontiers in Immunology
The role of the carbohydrate recognition domain of Placental Protein 13 (PP13) in pregnancy evaluated with recombinant PP13 and the DelT₂₂₁ PP13 VariantPLoS ONE

2013

Potential negative consequences of non-consented switch of inhaled medications and devices in asthma patientsInternational Journal of Clinical Practice
In vitro evaluation of pulmonary deposition of airborne volcanic ashAtmospheric Environment
Serum leptin concentrations, leptin mRNA expression, and food intake during the estrous cycle in ratsLaboratory animal research
Effects of placental protein 13 on the cardiovascular system in gravid and non-gravid rodentsFetal Diagnosis and Therapy
Placental protein 13 (PP13)Human Reproduction Update

2012

Anatomical and histological factors affecting intranasal drug and vaccine deliveryCurrent Drug Delivery
Clinical consequences following regulatory changes in respect to reimbursement of statins cost by the Icelandic Social Insurance AdministrationScandinavian Journal of Public Health

2011

History of Intranasal Delivery and the Nose.Pharm. Hist.

2010

Áhrif reglugerðarbreytingar á greiðsluþátttöku vegna statínlyfja á kólesterólgildi hjá sjúklingum með blóðþurrðarhjartasjúkdómaLæknablaðið

2008

ErratumReproductive Medicine and Biology
p-Chloroamphetamine-induced rat ejaculation is not associated with the preoptic nucleus or medial nucleus amygdalaReproductive Medicine and Biology

2007

Mucosal tolerance to KLH reduces BSA-induced arthritis in rats - An indication of bystander suppressionJournal of Clinical Immunology
Immunization prevents DDT buildup in mouse tissuesInternational Immunopharmacology

2006

Two intransal administration techniques give two different pharmacokinetic resultsScandinavian Journal of Laboratory Animal Science

2005

RhinoVax® is an efficient adjuvant in oral immunisation of young chickens and Cholera Toxin B is an effective oral primer in subcutaneous immunisation with Freunds's incomplete adjuvantIn Vivo
Induction of protective and specific antibodies against cocaine by intranasal immunisation using a glyceride adjuvantBiological and Pharmaceutical Bulletin

2004

Improving unbiased left/right training of rats and use of physostigmine to counteract scopolamine-induced short-term memory impairmentScandinavian Journal of Laboratory Animal Science

2003

The Initial Effects of Scopolamine on the Electroencephalogram in Healthy Human SubjectsAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

2002

Intranasal bioavailability of diazepam in sheep correlated to rabbit and manInternational Journal of Pharmaceutics

2001

Serum amyloid P component inhibits influenza A virus infectionsAntiviral Research
Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteersBritish Journal of Clinical Pharmacology

2000

Intranasal absorption of buprenorphine - In vivo bioavailability study in sheepInternational Journal of Pharmaceutics

1999

Intranasal immunization with pneumococcal polysaccharide conjugate vaccines protects mice against invasive pneumococcal infectionsInfection and Immunity
Single- and repeated-dose local toxicity in the nasal cavity of rabbits after intranasal administration of different glycols for formulations containing benzodiazepinesJournal of Pharmacy and Pharmacology
Intranasal administration of diazepam aiming at the treatment of acute seizuresBiological and Pharmaceutical Bulletin

1998

Intranasal vaccinationPharmaceutical Development and Technology
Intranasal vaccination of humans - Adjuvants and mechanismsProceedings of the Controlled Release Society
Selective augmentation of antibodies in various mucosal regions, after intranasal immunization with diphtheria in miceJournal of Pharmaceutical Sciences
Clinically relevant vaccine-vaccine interactionsBioDrugs

1997

Olfactory absorption of insulin to the brainDrug Delivery: Journal of Delivery and Targeting of Therapeutic Agents
ErratumInternational Journal of Pharmaceutics
Pharmacokinetic and pharmacodynamic response after intranasal administration of diazepam to rabbitsJournal of Pharmacy and Pharmacology
Intranasal booster vaccination against diphtheria and tetanus in manVaccine
Intranasal vaccination against diphtheria and tetanus in human subjectsVaccine Research
Solubilization of various benzodiazepines for intranasal administration, a pilot studyPharmaceutical Development and Technology

1996

Evaluation of local toxicity after repeated intranasal vaccination of guinea-pigsToxicology
Intranasal vaccination against influenza using pharmaceutical excipients as immunological adjuvantsVaccine Research
Optimal delivery of vaccines. Clinical pharmacokinetic considerationsClinical Pharmacokinetics
Selective delivery of insulin into the brainInternational Journal of Pharmaceutics
Intranasal administration of insulin to rabbits using glycofurol as an absorption promoterInternational Journal of Pharmaceutics

1995

Intranasal administration of diphtheria toxoid. Selecting antibody isotypes using formulations having various lipophilic characteristicsVaccine

1994

Local chemical irritation on mucosal surface, measured colorimetrically on the frog plate modelScandinavian Journal of Laboratory Animal Science
Pharmaceutical excipients and absorption promoters as immunostimulants reinforcing mucosal adjuvant (Cholera toxin B subunit)Vaccine Research

1993

Insulin and didecanoyl-L-α-phosphatidylcholineInternational Journal of Pharmaceutics
The relevance of nasal physiology to the design of drug absorption studiesAdvanced Drug Delivery Reviews

1992

Stimulation of the transepithelial flux of influenza HA vaccine by cholera toxin B subunitVaccine
The viability of isolated rabbit nasal mucosa in the Ussing chamber, and the permeability of insulin across the membraneInternational Journal of Pharmaceutics

1991

Insulin-Carrying Microspheres, in Vitro StudiesChemical and Pharmaceutical Bulletin
Study of Nasal Enzyme Activity towards InsulinChemical and Pharmaceutical Bulletin
Estimating Tissue Permeability And Other Bioelectrical Parameters Using Membrane Voltage And Short-Circuit CurrentChemical and Pharmaceutical Bulletin
Intranasal administration of insulin to humansDiabetes Research and Clinical Practice
Pharmacokinetics of intranasal drug administrationJournal of Pharmaceutical Sciences
The effect of cholera toxin and cholera toxin B subunit on the nasal mucosal membraneVaccine

1990

The influence of insulin and some excipients used in nasal insulin preparations on mucociliary clearanceInternational Journal of Pharmaceutics
Animal models for intranasal drug delivery studiesActa Pharmaceutica Nordica

1989

A simple flow injection analysis for studies of drug-protein binding interactions in serumActa Pharmaceutica Nordica
A simple flow-injection method for the determination of blood glucose using a Technicon immobilized enzyme coilJournal of Automatic Chemistry

1988

Activated carbon for the removal of the ointment base before kinetic assay of nitroglycerin ointmentFresenius' Zeitschrift für Analytische Chemie

Keywords for Specialisation:

Laboratory safety etc

Nasal drug delivery

Immunological adjuvants

Drug interactions

Drugs in pregnancy and lactation

Fetus drug delivery