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Forsíða

Elín Soffía Ólafsdóttir - Professor

Elín Soffía Ólafsdóttir

–

School of Health Sciences

Elín Soffía Ólafsdóttir

Professor

Professor of natural products chemistry

Location
Hagi / Ha-315
Phone
525 - 5804
Email
elinsol [at] hi.is

Unit
Faculty of Pharmaceutical Sciences

Published works

2024

The algal partnership is associated with quantitative variation of lichen specific metabolites in Cladonia foliacea from Central and Southern EuropeSymbiosis
A critical review of the edible seaweed Palmaria palmata (L.) Weber & Mohr and its bioactive compounds in the “omics” eraAlgal Research

2023

Flustramine Q, a Novel Marine Origin Acetylcholinesterase Inhibitor from Flustra foliaceaFuture Pharmacology
Mycobiont-specific primers facilitate the amplification of mitochondrial small subunit ribosomal DNAMycoKeys

2022

Novel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichensPhytochemistry
Novel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichensPhytochemistry

2021

Invasive and in situ squamous cell carcinoma of the skinBritish Journal of Dermatology

2020

Phylogenetic diversity of the lichenized algal genus Trebouxia (Trebouxiophyceae, Chlorophyta): a new lineage and novel insights from fungal-algal association patterns of Icelandic cetrarioid lichens (Parmeliaceae, Ascomycota)Botanical Journal of the Linnean Society
Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro ConfirmationMolecules
Phylogenetic diversity of the lichenized algal genus Trebouxia (Trebouxiophyceae, Chlorophyta): a new lineage and novel insights from fungal-algal association patterns of Icelandic cetrarioid lichens (Parmeliaceae, Ascomycota)Botanical Journal of the Linnean Society
Basal cell carcinomaBritish Journal of Dermatology

2019

Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells.Free Radical Biology and Medicine
Ethnopharmacology of the club moss subfamily Huperzioideae (Lycopodiaceae, Lycopodiophyta)Journal of Ethnopharmacology
Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cellsFree Radical Biology and Medicine
Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytesInternational Immunopharmacology
Novel Approach for the Search for Chemical Scaffolds with Activity at Both Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor: A Perspective on Scaffolds with Dual Activity for the Treatment of Neurodegenerative DisordersMolecules
Alkaloid fingerprinting resolves Huperzia selago genotypes in IcelandBiochemical Systematics and Ecology
Alkaloids fingerprinting resolves Huperzia selago genotypes in Iceland.Biochemical Systematics and Ecology

2018

Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS chemical profiling and DNA barcodingFood Chemistry
Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptorsBritish Journal of Pharmacology
Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago ComplexPlanta Medica
Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS metabolite profiling and DNA barcoding.Food Chemistry

2017

DNA barcoding and LC-MS metabolite profiling of the lichen-forming genus Melanelia: Specimen identification and discrimination focusing on Icelandic taxaPLoS ONE
Investigations on the constituents of SagaPro tablets, a food supplement manufactured from Angelica archangelica leafPharmazie

2016

Secondary metabolites from cetrarioid lichensPhytomedicine

2015

Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses toward a Th2/Treg phenotypePhytomedicine
The Genus Diphasiastrum and Its Lycopodium AlkaloidsPlanta Medica
Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17⁺RORγt⁺/IL-10⁺FoxP3⁺ ratio in CD4⁺ T cellsImmunology Letters
Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses towards a Th2/Treg phenotype.Phytomedicine
Cutaneous melanoma in IcelandJournal of the European Academy of Dermatology and Venereology

2014

A heteroglycan from the cyanobacterium Nostoc commune modulates LPS-induced inflammatory cytokine secretion by THP-1 monocytes through phosphorylation of ERK1/2 and AktPhytomedicine

2013

Lycopodium alkaloids
Biodiversity of benthic invertebrates and bioprospecting in Icelandic watersPhytochemistry Reviews
Biodiversity of benthic invertebrates and bioprospecting in Icelandic watersPhytochemistry Reviews
Structural characterisation of a complex heteroglycan from the cyanobacterium Nostoc communeCarbohydrate Polymers
Phytochemical analysis of alkaloids from the Icelandic club moss Diphasiastrum alpinumPhytochemistry Letters

2012

Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitroPhytomedicine
Synergistic cytotoxic effect of the microtubule inhibitor marchantin a from marchantia polymorpha and the aurora kinase inhibitor MLN8237 on breast cancer cells in vitroPlanta Medica

2011

Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitroImmunology Letters

2010

Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestrePhytochemistry
Immunomodulating effects of extracts from Icelandic marine invertebratesPlanta Medica
Structural characterisation of a new O-methylated heteroglycan, colleman, from the cyanolichen Collema flaccidumCarbohydrate Polymers

2009

Search for the optimal dose interval of adrenocorticotrophic hormone (ACTH_1-24) with regard to the lipid-lowering effectBasic and Clinical Pharmacology and Toxicology

2008

In vitro and in vivo immunomodulating effects of traditionally-prepared extract and purified compounds from Cetraria islandicaProceedings of the Nutrition Society
In vitro and in vivo immunomodulating effects of traditionally prepared extract and purified compounds from Cetraria islandicaInternational Immunopharmacology
In vitro and in vivo immunomodulating effects of traditonally prepared extracts and purified compounds from Cetraria islandica.International Immunopharmacology

2007

Alkalóíðar úr íslenskum jöfnum.RAUST - Tímarit um raunvísindi og stærðfræði
Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformisPhytomedicine

2006

Structural characterisation of a highly branched galactomannan from the lichen Peltigera canina by methylation analysis and NMR-spectroscopyCarbohydrate Polymers
Structural characterisation of novel heteroglycans by NMR spectroscopy and methylationanalysis.Carbohydrate Research
Structural characterization of a highly branched galactomannan from the lichen Peltigeracanina by methylation analysis and NMR spectroscopy.Carbohydrate Polymers
Structural characterisation of novel lichen heteroglycans by NMR spectroscopy and methylation analysisCarbohydrate Research
Structural characterisation of novel lichen heteroglycans by NMR spectroscopy and methylation analysis.Carbohydrate Research
Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cellsInternational Immunopharmacology
Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanismsAtherosclerosis
Structural characterisation of a highly branched galactomannan from the lichen Peltigera canina by methylation analysis and NMR-spectroscopy.Carbohydrate Polymers

2005

Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-α secretion by rat peritoneal macrophages in vitroPhytomedicine

2004

Selagoline, a new alkaloid from Huperzia selagoNatural Product Research

2003

Immunologically active 06-branched (1→3)-β-glucan from the lichen Thamnolia vermicularis var. subuliformisPhytomedicine

2002

Cyanogenesis in glucosinolate-producing plantsPhytochemistry
Chromatography and electrophoresis in separation and characterization of polysaccharides from lichensJournal of Chromatography A
Cyanogenic glycosides of Passiflora: Distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseutocyanogenic -hydroxyamines as isolation artefactsPhytochemistry

2001

Polysaccharides from lichensPlanta Medica
Constituents of three Icelandic Alchemilla speciesBiochemical Systematics and Ecology

2000

TT virus infections among blood donors in IcelandTransfusion

1999

Immunologically active (1→3)-(1→4)-α-D-Glucan from Cetraria islandicaPhytomedicine
Rhamnopyranosylgalactofuranan, a new immunologically active polysaccharide from Thamnolia subuliformisPhytomedicine

1997

Comparison of NCEP performance specifications for triglycerides, HDL-, and LDL-cholesterol with operating specifications based on NCEP clinical and analytical goalsClinical Chemistry

1996

Matrix effects and the performance and selection of quality-control procedures to monitor PO₂ measurementsClinical Chemistry

1993

Quality Status of Serum Cholesterol Analysis in IcelandUpsala Journal of Medical Sciences

1992

Substrate specificity in the biosynthesis of cyclopentanoid cyanohydrin glucosidesPhytochemistry
Transferability of clinical laboratory data within a health care regionScandinavian Journal of Clinical and Laboratory Investigation

1991

Cyanohydrin glycosides with unusual sugar residuesPhytochemistry
Structure Determination of Natural Epoxycyclopentanes by X-ray Crystallography and NMR SpectroscopyJournal of Organic Chemistry

1990

Cyanohydrin glucosides of turneraceaeBiochemical Systematics and Ecology
Influence of dietary cod liver oil on fatty acid composition of plasma lipids in human male subjects after myocardial infarctionJournal of Internal Medicine
The Regional Transferability ProjectUpsala Journal of Medical Sciences

1989

Cyclopentenoid cyanohydrin glycosides with unusual sugar residues.Acta chemica Scandinavica (Copenhagen, Denmark : 1989)
Cyanohydrin glycosides of passifloraceaePhytochemistry

1987

Cyanogenesis of adenia volkensii Harms and tetrapathaea tetrandra Cheeseman (Passifloraceae) revisited: tetraphyllin B and volkenin. Optical rotatory power of cyclopentenoid cyanohydrin glucosides.Acta Chemica Scandinavica
Biochemistry in IcelandBiochemical Education
Monohydroxylated cyclopentenone cyanohydrin glucosides of Flacourtiaceae.Phytochemistry

1986

Natural glycosides of cyclopentenone cyanohydrinsTetrahedron Letters

Keywords for Specialisation:

Natural product chemistry

Medicinal chemistry

Bioactive natural products