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Snorri Þór Sigurðsson - Prófessor

Snorri Þór Sigurðsson

–

Verkfræði- og náttúruvísindasvið

Snorri Þór Sigurðsson

Prófessor

Aðsetur
Dunhagi 3 / Rau-122
Sími
5254801
Tölvupóstur
snorrisi [hjá] hi.is

Starfseining
Raunvísindadeild
Vefsíða
http://www.hi.is/~snorrisi/

Ferilskrá
Snorri Þór Sigurðsson - ferilskrá
ORCID vefsíða
https://orcid.org/0000-0003-2492-1456
Rannsóknagátt – Snorri Þór Sigurðsson

Útgefið efni

2024

AsymPol-TEKs as efficient polarizing agents for MAS-DNP in glass matrices of non-aqueous solventsPhysical Chemistry Chemical Physics
Topological Heterogeneity of Protein Kinase C Modulators in Human T-Cells Resolved with In-Cell Dynamic Nuclear Polarization NMR SpectroscopyJournal of the American Chemical Society
Role of Protons in and around Strongly Coupled Nitroxide Biradicals for Cross-Effect Dynamic Nuclear PolarizationJournal of Physical Chemistry Letters
Förster resonance energy transfer within the neomycin aptamerPhysical Chemistry Chemical Physics
Frequency-Chirped Magic Angle Spinning Dynamic Nuclear Polarization Combined with Electron DecouplingJournal of Physical Chemistry Letters
Structure and Internal Dynamics of Short RNA Duplexes Determined by a Combination of Pulsed EPR Methods and MD SimulationsAngewandte Chemie - International Edition

2023

Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent MicellesACS Omega
PyrroTriPolChemical Science
Frequency-swept dynamic nuclear polarizationJournal of Magnetic Resonance
Simultaneous Localization of Two High Affinity Divalent Metal Ion Binding Sites in the Tetracycline RNA Aptamer with Mn²⁺-Based Pulsed Dipolar EPR SpectroscopyJournal of Physical Chemistry Letters
Fast magic angle spinning for the characterization of milligram quantities of organic and biological solids at natural isotopic abundance by ¹³C–¹³C correlation DNP-enhanced NMRSolid State Nuclear Magnetic Resonance
Solid-Effect Dynamic Nuclear Polarization in Viscous Liquids at 9.4 T Using Narrow-Line Polarizing AgentsJournal of the American Chemical Society

2022

Highly Efficient Polarizing Agents for MAS‐DNP of Proton‐Dense Molecular SolidsAngewandte Chemie International Edition
Highly Efficient Polarizing Agents for MAS-DNP of Proton-Dense Molecular SolidsAngewandte Chemie - International Edition

2021

A Carbazole-Derived Nitroxide That Is an Analogue of CytidineJournal of Organic Chemistry
The distance between g-tensors of nitroxide biradicals governs MAS-DNP performanceJournal of Magnetic Resonance

2020

Compaction of RNA Duplexes in the Cell**Angewandte Chemie - International Edition
Noncovalent Spin‐Labeling of DNA and RNA TriplexesChemistry & Biodiversity
Nitroxide‐Derived N‐Oxide Phenazines for Noncovalent Spin‐Labeling of DNAChemBioChem
Water-soluble BDPA radicals with improved persistenceChemical Communications
Dynamic Nuclear Polarization with Electron Decoupling in Intact Human Cells and Cell LysatesJournal of Physical Chemistry B
Characterization of frequency-chirped dynamic nuclear polarization in rotating solidsJournal of Magnetic Resonance
Reduction Resistant and Rigid Nitroxide Spin-Labels for DNA and RNAThe Journal of Organic Chemistry
On the Limited Stability of BDPA RadicalsChemistry – A European Journal

2019

Benzoyl-Protected Hydroxylamines for Improved Chemical Synthesis of Oligonucleotides Containing Nitroxide Spin LabelsEuropean Journal of Organic Chemistry
Paramagnetic-iterative relaxation matrix approachJournal of Biomolecular NMR
High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin labelNucleic Acids Research
Sensitivity analysis of magic angle spinning dynamic nuclear polarization below 6 KJournal of Magnetic Resonance
Frequency-chirped dynamic nuclear polarization with magic angle spinning using a frequency-agile gyrotronJournal of Magnetic Resonance

2018

Efficiency of Water-Soluble Nitroxide Biradicals for Dynamic Nuclear Polarization in Rotating Solids at 9.4 TChemistry - A European Journal
Influence of Mg2+ on the conformational flexibility of a tetracycline aptamerRNA
Orientation Selective 2D-SIFTER Experiments at X-Band FrequenciesApplied Magnetic Resonance
Dynamics of Nucleic Acids at Room Temperature Revealed by Pulsed EPR SpectroscopyAngewandte Chemie International Edition
Dynamic Nuclear Polarization Nuclear Magnetic Resonance in Human Cells Using Fluorescent Polarizing AgentsBiochemistry
Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamerNucleic Acids Research
A semi-rigid isoindoline-derived nitroxide spin label for RNAOrganic & Biomolecular Chemistry
Computationally Assisted Design of Polarizing Agents for Dynamic Nuclear Polarization Enhanced NMRJournal of the American Chemical Society
Corrigendum to “Quantitative UPLC–MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency” [J. Chromatogr. B 1036–1037 (2016) 170–177] (S1570023216308467) (10.1016/j.jchromb.2016.09.018))Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Noncovalent spin-labeling of RNA: the aptamer approachChemical Communications

2017

Spin the light offPhysical Chemistry Chemical Physics
Impact of spin label rigidity on extent and accuracy of distance information from PRE dataJournal of Biomolecular NMR
Characterization of V-Mo-W Mixed Oxide Catalyst Surface Species by ⁵¹V Solid-State Dynamic Nuclear Polarization NMRJournal of Physical Chemistry C
Determination of helix orientations in a flexible DNA by multi-frequency EPR spectroscopyPhysical Chemistry Chemical Physics

2016

Quantitative UPLC–MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiencyJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
EPR spectroscopy for the study of RNA-ligand interactions
Flexibility and conformation of the cocaine aptamer studied by PELDORPhysical Chemistry Chemical Physics
Site-directed spin labeling for EPR studies of nucleic acids
Noncovalent and site-directed spin labeling of duplex RNAChemical Communications
Frequency-agile gyrotron for electron decoupling and pulsed dynamic nuclear polarizationJournal of Magnetic Resonance
bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomoleculesChemical Communications
Dynamic Nuclear Polarization Provides New Insights into Chromophore Structure in Phytochrome PhotoreceptorsAngewandte Chemie - International Edition
Flexibilities of isoindoline-derived spin labels for nucleic acids by orientation selective PELDORPhysical Chemistry Chemical Physics

2015

Site-directed spin labeling of 2′-amino groups in RNA with isoindoline nitroxides that are resistant to reductionChemical Communications
CorrectionPhysical Chemistry Chemical Physics
Distance measurements between manganese(ii) and nitroxide spin-labels by DEER determine a binding site of Mn2+ in the HP92 loop of ribosomal RNAPhysical Chemistry Chemical Physics
Natural Abundance 15N NMR by Dynamic Nuclear Polarization: Fast Analysis of Binding Sites of a Novel Amine-Carboxyl-Linked Immobilized Dirhodium CatalystChemistry - A European Journal
Pulsed EPR dipolar spectroscopy at Q- and G-band on a trityl biradicalPhysical Chemistry Chemical Physics
TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopyBeilstein Journal of Organic Chemistry
Conformational dynamics of nucleic acid molecules studied by PELDOR spectroscopy with rigid spin labelsJournal of Magnetic Resonance
Site-Directed Spin Labeling of RNA by Postsynthetic Modification of 2′-Amino Groups
Advanced EPR Methods for Studying Conformational Dynamics of Nucleic Acids

2014

TMIO-pyrimid hybrids are profluorescent, site-directed spin labels for nucleic acidsOrganic Letters
Sterically shielded spin labels for in-cell EPR spectroscopy: Analysis of stability in reducing environmentFree Radical Research
Modified RNAs as Tools in RNA Biochemistry
Conformationally Restricted Isoindoline-Derived Spin Labels in Duplex DNA: Distances and Rotational Flexibility by Pulsed Electron-Electron Double Resonance SpectroscopyChemistry - A European Journal
Nitroxide-labeled pyrimidines for non-covalent spin-labeling of abasic sites in DNA and RNA duplexesOrganic and Biomolecular Chemistry

2013

Rigid 5′-6-locked phenanthroline-derived nucleosides chelated to ruthenium and europium ionsBioorganic and Medicinal Chemistry Letters
Syntheses and photophysical properties of 5′-6-locked fluorescent nucleosidesOrganic and Biomolecular Chemistry
Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiationPhysical Chemistry Chemical Physics
A single-stranded junction modulates nanosecond motional ordering of the substrate recognition duplex of a group i ribozymeChemBioChem
Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin labeling and PELDORNucleic Acids Research
Measurements of short distances between trityl spin labels with CW EPR, DQC and PELDORPhysical Chemistry Chemical Physics
Site-directed nitroxide spin labeling of biopolymersStructure and Bonding
Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acidsChemical Communications

2012

W-band PELDOR with 1 kW microwave powerJournal of Magnetic Resonance
Conformation and dynamics of nucleotides in bulges and symmetric internal loops in duplex DNA studied by EPR and fluorescence spectroscopiesBiochemical and Biophysical Research Communications
Synthesis and characterization of RNA containing a rigid and nonperturbing cytidine-derived spin labelJournal of Organic Chemistry
Effect of N3 Modifications on the Affinity of Spin Label ç for Abasic Sites in Duplex DNAChemBioChem
Trityl radicalsChemistry - A European Journal
Mass spectrometric study on sodium ion induced central nucleotide deletion in the gas phaseJournal of the American Society for Mass Spectrometry
Structural changes of an abasic site in duplex DNA affect noncovalent binding of the spin label ÇNucleic Acids Research
Site-directed spin labelling of nucleic acidsEuropean Journal of Organic Chemistry

2011

Structure-Function Relationships of Phenoxazine Nucleosides for Identification of Mismatches in Duplex DNA by Fluorescence SpectroscopyChemBioChem
Simulating electron spin resonance spectra of macromolecules labeled with two dipolar-coupled nitroxide spin labels from trajectoriesPhysical Chemistry Chemical Physics
Nitroxides and nucleic acidsPure and Applied Chemistry
Conformational flexibility of DNAJournal of the American Chemical Society
Experimental and theoretical study of the metastable decay of negatively charged nucleosides in the gas phasePhysical Chemistry Chemical Physics
Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probeNucleic Acids Research

2010

Analytical method to determine the orientation of rigid spin labels in DNAPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Site-directed spin-labeling of nucleic acids by click chemistryJournal of the American Chemical Society
Noncovalent and site-directed spin labeling of nucleic acidsAngewandte Chemie - International Edition
Large flanking sequence effects in single nucleotide mismatch detection using fluorescent nucleoside Ç^fBioorganic and Medicinal Chemistry
Synthesis of a 5′-6-locked, 1,10-phenanthroline-containing nucleoside and its incorporation into DNAEuropean Journal of Organic Chemistry

2009

Relative orientation of rigid nitroxides by peldorAngewandte Chemie - International Edition
Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopyFEBS Journal
Conformational equilibria of bulged sites in duplex DNA studied by EPR spectroscopyJournal of Physical Chemistry B
Folding of the cocaine aptamer studied by EPR and fluorescence spectroscopies using the bifunctional spectroscopic probe ÇNucleic Acids Research
Ferro- and antiferromagnetic exchange coupling constants in PELDOR spectraPhysical Chemistry Chemical Physics
Studying RNA using site-directed spin-labeling and continuous-wave electron paramagnetic resonance spectroscopy.Methods in Enzymology
Identification of single-base mismatches in duplex DNA by EPR spectroscopyJournal of the American Chemical Society

2008

Single base interrogation by a fluorescent nucleotideChemical Communications
tert-Butyldimethylsilyl O-protected chitosan and chitooligosaccharidesCarbohydrate Research
Theory for spin-lattice relaxation of spin probes on weakly deformable DNAJournal of Physical Chemistry B
Modified RNAs as Tools in RNA Biochemistry
Rigid spin-labeled nucleoside ÇNucleic Acids Research
"Succinimidyl ester," in Nucleic Acids from A to Z
A nonafluoro nucleoside as a sensitive ¹⁹F NMR probe of nucleic acid conformationOrganic Letters

2007

A nucleoside that contains a rigid nitroxide spin labelAngewandte Chemie - International Edition
Site-specific incorporation of nitroxide spin-labels into 2′-positions of nucleic acidsNature Protocols

2006

Kjarnsýruefnasmíðar og rannsóknir á kjarnsýrum með rafeindaspunatækni
Using solid-state ³¹P{¹⁹F} REDOR NMR to measure distances between a trifluoromethyl group and a phosphodiester in nucleic acidsJournal of Magnetic Resonance

2005

Use of enzymes in organic synthesisJournal of Chemical Education
Investigation of Mg²⁺- and temperature-dependent folding of the hairpin ribozyme by photo-crosslinkingNucleic Acids Research
Identification of amino acids that promote specific and rigid TAR RNA-Tat protein complex formationChemistry and Biology
Monitoring tat peptide binding to TAR RNA by solid-state ³¹P-¹⁹F REDOR NMRNucleic Acids Research
Spin labeled nucleic acids for ERP spectroscopic study of DNA and RNA structure and dynamicsInstitute of Organic Chemistry and Biochemistry
Isolation and characterization of a thermostable RNA ligase 1 from a Thermus scotoductus bacteriophage TS2126 with good single-stranded DNA ligation propertiesNucleic Acids Research
EPR spectroscopic analysis of U7 hammerhead ribozyme dynamics during metal ion induced foldingBiochemistry

2004

Sequence context effect on the structure of nitrous acid induced DNA interstrand cross-linksNucleic Acids Research
Chemical syntheses of inhibitory substances of the RNA-RNA ligation reaction catalyzed by the hairpin ribozymeNucleic Acids Research
A new α-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse IIIEMBO Journal
Interactions of the antibiotics neomycin B and chlortetracycline with the hammerhead ribozyme as studied by Zn²⁺-dependent RNA cleavageBioorganic and Medicinal Chemistry
Solution structure of a nitrous acid induced DNA interstrand cross-linkNucleic Acids Research

2003

Structural investigation of a high-affinity Mn^II binding site in the hammerhead ribozyme by EPR spectroscopy and DFT calculations. Effects of neomycin B on metal-ion bindingChemBioChem
Unexpected formation of 2′-deoxy-N3-(3,3,3-trifluoro-1-propenyl)uridine via a Michael-type addition to 3,3,3-trifluoropropyneTetrahedron Letters
Determination of DNA minor groove width in distamycin-DNA complexes by solid-state NMRNucleic Acids Research
Zinc-dependent cleavage in the catalytic core of the hammerhead ribozymeNucleic Acids Research
Stereospecific syntheses of 3′-deuterated pyrimidine nucleosides and their site-specific incorporation into DNAOrganic Letters
EPR spectroscopic analysis of TAR RNA-metal ion interactionsBiochemical and Biophysical Research Communications
Nanometer distance measurements on RNA using PELDORJournal of the American Chemical Society

2002

Transition state stabilization by a catalytic RNAScience
Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognitionBiochemistry
Investigation of RNA-protein and RNA-metal ion interactions by Electron paramagnetic resonance spectroscopyChemistry and Biology

2001

Identification and characterization of a divalent metal ion-dependent cleavage site in the hammerhead ribozymeBiochemistry
Preparation of base-deuterated 2′-deoxyadenosine nucleosides and their site-specific incorporation into DNANucleosides, Nucleotides and Nucleic Acids
Site-specific incorporation of nitroxide spin-labels into internal sites of the TAR RNA; structure-dependent dynamics of RNA by EPR spectroscopy [15]Journal of the American Chemical Society
Incorporation of 2′-deoxy-5-(trifluoromethyl)uridine and 5-cyano-2′-deoxyuridine into DNABioorganic and Medicinal Chemistry Letters

2000

Monoalkylation of DNA by reductively activated FR66979Bioorganic and Medicinal Chemistry
Interstrand disulfide cross-linking of internal sugar residues in duplex RNABioorganic and Medicinal Chemistry
Chemical synthesis of cross-link lesions found in nitrous acid treated DNAJournal of Organic Chemistry
[12] Site-specific sulfhydryl groups for study of RNA conformation via disulfide cross-linkingMethods in Enzymology

1999

Quantification of formaldehyde-mediated covalent adducts of adriamycin with DNABiochemistry
Thiol-containing RNA for the study of structure and function of ribozymesMethods: A Companion to Methods in Enzymology
Chemical synthesis and preliminary structural characterization of a nitrous acid interstrand cross-linked duplex DNAJournal of the American Chemical Society
Long-range distance measurements to the phosphodiester backbone of solid nucleic acids using ³¹P-¹⁹F REDOR NMRJournal of the American Chemical Society

1997

Inter-domain cross-linking and molecular modelling of the hairpin ribozymeJournal of Molecular Biology

1996

In vitro selection of hammerhead ribozymes containing a bulged nucleotide in stem IINucleic Acids Research
Isolation of oligoribonucleotides containing intramolecular cross-linksAnalytical Biochemistry
A mild and simple method for the preparation of isocyanates from aliphatic amines using trichloromethyl chloroformate. synthesis of an isocyanate containing an activated disulfideJournal of Organic Chemistry
An NMR study of [d(CGCGAATTCGCG)]₂ containing an interstrand cross-link derived from a distamycin-pyrrole conjugateNucleic Acids Research

1995

Probing RNA tertiary structureRNA
Structure-function relationships of hammerhead ribozymesTrends in Biotechnology

1994

Synthesis and reactions with DNA of a family of DNA-DNA afinity cross-linking agentsTetrahedron

1993

DNA Interstrand Cross-Linking by Reductively Activated FR900482 and FR66979Journal of the American Chemical Society
DNA Interstrand Cross-Linking Reactions of Pyrrole-Derived, Bifunctional ElectrophilesJournal of the American Chemical Society
Affinity Cross-Linking of Duplex DNA by a Pyrrole-Oligopeptide ConjugateJournal of the American Chemical Society

1992

Interstrand Cross-Linking of Duplex DNA by Nitrous AcidJournal of the American Chemical Society

1991

Sequence preferences of DNA interstrand cross-linking agentsTetrahedron

1990

Sequence Preferences of DNA Interstrand Cross-Linking AgentsBiochemistry

1989

The preparation of triglycerides highly enriched with ω-3 polyunsaturated fatty acids via lipase catalyzed interesterificationTetrahedron Letters

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