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Rafn Benediktsson - Prófessor

Rafn Benediktsson

–

Heilbrigðisvísindasvið

Rafn Benediktsson

Prófessor

Forstöðulæknir bráða,- lyflækninga og endurhæfingarþjónustu Landspítala

Aðsetur
LSH - Fossvogi
Sími
543 1000
Tölvupóstur
rafn [hjá] hi.is

Starfseining
Læknadeild
Vefsíða
http://www.uni.hi.is/rafn

ORCID vefsíða
https://orcid.org/0000-0002-2954-9801
Rannsóknagátt – Rafn Benediktsson

Útgefið efni

2023

Data from Loss-of-Function Variants in the Tumor-Suppressor Gene <i>PTPN14</i> Confer Increased Cancer Risk
Supplementary Material from Loss-of-Function Variants in the Tumor-Suppressor Gene <i>PTPN14</i> Confer Increased Cancer Risk
Reynsla kvenna af því að greinast með meðgöngusykursýki og vitneskja þeirra um mikilvægi eftirfylgdar eftir fæðinguTímarit hjúkrunarfræðinga

2022

Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particlesEuropean Journal of Preventive Cardiology

2021

Ofþyngd þjóðar – hvað getum við gert?Læknablaðið
Distinction between the effects of parental and fetal genomes on fetal growthNature Genetics
Distinction between the effects of parental and fetal genomes on fetal growth.Nature Genetics
Ofþyngd þjóðar - hvað getum við gert?Læknablaðið
Caffeine exposure from beverages and its association with self-reported sleep duration and quality in a large sample of Icelandic adolescentsFood and Chemical Toxicology
Loss-of-function variants in the tumor-suppressor gene PTPN14 confer increased cancer riskCancer Research

2020

FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid diseaseNature

2019

Sequence variants associating with urinary biomarkersHuman Molecular Genetics
The number of adults with incident type 1 diabetes phenotype in Iceland is half the number in children – A population based studyDiabetes Research and Clinical Practice
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fracturesNature Communications
Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and DiabetesJournal of the American College of Cardiology
A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathyNature Communications
Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes.Journal of the American College of Cardiology
Publisher CorrectionNature Communications
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.Nature Communications

2018

Sjúkratilfelli: Truflun á starfsemi heiladinguls vegna ópíóíðaLæknablaðið
Sequence variants associating with urinary biomarkersHuman Molecular Genetics

2017

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlationsnpj Genomic Medicine
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlationsnpj Genomic Medicine
An Expanded Genome-Wide Association Study of Type 2 Diabetes in EuropeansDiabetes
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritabilityNature Genetics

2015

The epidemiology of pituitary adenomas in Iceland, 1955-2012European Journal of Endocrinology
HbA1c 7% verður 53 mmól/mól -ný eining frá 1. mars 2015Laeknabladid
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility lociNature Genetics

2014

Loss-of-function mutations in SLC30A8 protect against type 2 diabetesNature Genetics
Adipose tissue, muscle, and functionDiabetes Care
Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 DiabetesPLoS Genetics
Frá embætti landlæknis. Vanstarfsemi í skjaldkirtliLaeknabladid
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetesNature Genetics
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityNature Genetics

2013

Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studiesBMC Public Health

2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesNature Genetics
Greining, meðferð og eftirlit háþrýstingsLaeknabladid
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.PLoS Genetics
Early life residency associated with the risk of developing type 2 diabetes - The population-based Reykjavík Study.Læknablaðið
Retinopathy in old persons with and without diabetes mellitusDiabetologia
Greining, medferd og eftirlit háprýstings.Læknabladid
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese casesPLoS Genetics
Tengsl búsetu fyrstu 20 æviárin við áhættu á sykursýki af tegund 2Laeknabladid
A genome-wide association search for type 2 diabetes genes in African Americans.PLoS ONE

2011

ErratumNature Genetics
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1American Journal of Human Genetics
Meðhöndlun sykursýki af tegund 1 hjá fullorðnum - er búið að leysa málið?Laeknabladid
Effects of statin medication on mortality risk associated with type 2 diabetes in older persons: the population-based AGES-Reykjavik StudyBMJ Open
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesDiabetes
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traitsPLoS Genetics

2010

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskNature Genetics
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisNature Genetics
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskNature Genetics
ErratumNature Genetics

2009

Unfavourable risk factors for type 2 diabetes mellitus are already apparent more than a decade before onset in a population-based study of older personsEuropean Journal of Epidemiology
Sjálfsumönnun og sjálfsefling fólks með sykursýki: tillaga að nálgun með leiðbeinandi matskvörðum – yfirlitsgrein.Læknablaðið
Instruments to tailor care of people with type 2 diabetesJournal of Advanced Nursing
Parental origin of sequence variants associated with complex diseasesNature
Sjálfsumönnun og sjálfsefling fólks meö sykursýki Tillaga aö nálgun meö leiöbeinandi matskvöröum - yfirlitsgreinLaeknabladid

2008

Einkenni og teikn fótameins hjá íslenskum sjúklingum meǒ sykursýki af tegund 2Laeknabladid
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysmNature Genetics
Reliability and validity of the Icelandic version of the problem area in diabetes (PAID) scaleInternational Journal of Nursing Studies

2007

Infant feeding patterns and midlife erythrocyte sedimentation rateActa Paediatrica, International Journal of Paediatrics
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetesNature Genetics
Outcomes of educational interventions in type 2 diabetesPatient Education and Counseling
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionNature Genetics
A variant in CDKAL1 influences insulin response and risk of type 2 diabetesNature Genetics
Algengi sykursýki af tegund tvö á Islandi 1967-2002.Læknabladid

2006

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics

2005

Mótefnatengd sykursýki af tegund 2 á IslandiLæknabladid

2004

Maximizing the benefit of treatment in mild hypertensionQJM - Monthly Journal of the Association of Physicians
Mótefnatengd sykursýki af tegund 2 á Íslandi: algengi, svipgerð og skyldleiki einstaklinga.Læknablaðið
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight populationEuropean Journal of Clinical Nutrition

2003

Þrjár einfaldar leiðir til nákvæmari greiningar háþrýstingsLæknablaðið
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2American Journal of Human Genetics

2002

Háþrýstingur með kalíumbresti : óvenjuleg sýnd litfíklaæxlis : sjúkratilfelliLæknablaðið
Size at birth and coronary heart disease in a population of high birth weight.American Journal of Clinical Nutrition
Relationship between size at birth and hypertension in a genetically homogenous population of high birth weightJournal of Hypertension
Size at birth and coronary artery disease in a population with high birth weightAmerican Journal of Clinical Nutrition
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight populationAmerican Journal of Clinical Nutrition

2000

Transfer and metabolism of prostaglandin E2 in the dually perfused human placenta.Placenta
Transfer and metabolism of prostaglandin E₂ in the dual perfused human placentaPlacenta

1998

Tissue-specific messenger ribonucleic acid expression of 11β- hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid actionEndocrinology
Understanding human parturition [6]Lancet
Meðferð sykursýki af tegund 2 : bresk tímamótarannsókn styður góða blóðsykur- og blóðþrýstingsstjórn [ritstjórnargrein]Læknablaðið
Management of the unexpected resultPostgraduate Medical Journal

1997

Placental 11ß-hydroxysteroid dehydrogenase: A key regulator of human fetal glucocorticoid exposure.Clinical Endocrinology
Lack of effect of nicotine or ethanol on the activity of 11β- hydroxysteroid dehydrogenase type 2Journal of Steroid Biochemistry and Molecular Biology
Placental 11β-hydroxysteroid dehydrogenaseClinical Endocrinology

1996

Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the ratPlacenta
11β-Hydroxysteroid dehydrogenasesSteroids
11β-Hydroxysteroid dehydrogenase type 2 in the rat corpus luteumEndocrinology
11β-Hydroxysteroid dehydrogenasesEssays in Biochemistry
Essential hypertensionClinical Endocrinology

1995

Cellular selectivity of aldosterone actionCurrent Opinion in Nephrology and Hypertension
Fetal osteocalcin levels are related to placental 11β-hydroxysteroid dehydrogenase activity in humansClinical Endocrinology
Ambulatory blood pressure monitoringJournal of Human Hypertension
Placental 11β-hydroxysteroid dehydrogenase and the programming of hypertensionJournal of Steroid Biochemistry and Molecular Biology

1994

Apparent mineralocorticoid excessJournal of Human Hypertension

1993

Glucocorticoid exposure in uteroThe Lancet
Dysfunction of placental glucocorticoid barrierThe Lancet
Congenital and acquired syndromes of apparent mineralocorticoid excessJournal of Steroid Biochemistry and Molecular Biology

1992

11ß-hydroxysteroid dehydrogenase in the ovary: High expression in the oocyte.Journal of Endocrinological Investigation
11β-Hydroxysteroid dehydrogenase in the rat ovaryJournal of Endocrinology
Blood pressure and birth weightJournal of Hypertension
Dexamethasone treatment of pregnant rats leads to raised blood pressure in the offspringJournal of Hypertension

1991

Natural history of chronic left ventricular aneurysm; A population based cohort studyJournal of Clinical Epidemiology
LiquoriceThe Lancet

1989

Cod liver oil and atherosclerosis.Læknablaðið

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