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Pétur Orri Heiðarsson - Prófessor

Pétur Orri Heiðarsson

–

Verkfræði- og náttúruvísindasvið

Pétur Orri Heiðarsson

Prófessor

Prófessor

Aðsetur
Askja / N-346
Sími
5254276 8951508
Tölvupóstur
pheidarsson [hjá] hi.is

Starfseining
Líf- og umhverfisvísindadeild
Vefsíða
https://heidarsson.hi.is/

ORCID vefsíða
https://orcid.org/0000-0003-2027-5434
Rannsóknagátt – Pétur Orri Heiðarsson

Útgefið efni

2024

PED in 2024Nucleic Acids Research
DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2Nature Communications
Novel mechanisms of MITF regulation identified in a mouse suppressor screenEMBO Reports

2023

Multifunctional Intrinsically Disordered Regions in Transcription FactorsChemistry - A European Journal
Author Correction: Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexesNature Communications
Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding ProcessJournal of the American Chemical Society

2022

Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered proteinNature Chemistry

2021

Disorder in a two-domain neuronal Ca²⁺-binding protein regulates domain stability and dynamics using ligand mimicryCellular and Molecular Life Sciences
From folding to functionEssays in Biochemistry
Protein intrinsic disorder on a dynamic nucleosomal landscape

2020

Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexesNature Communications
Effects of Ligand Binding on the Energy Landscape of Acyl-CoA-Binding ProteinBiophysical Journal
Binding without folding – the biomolecular function of disordered polyelectrolyte complexesCurrent Opinion in Structural Biology

2018

Extreme disorder in an ultrahigh-affinity protein complexNature
The complex conformational dynamics of neuronal calcium sensor-1Frontiers in Molecular Neuroscience

2015

Single-Molecule Folding Mechanisms of the apo- and Mg²⁺-Bound States of Human Neuronal Calcium Sensor-1Biophysical Journal

2014

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligandsJournal of Biological Chemistry
Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1Proceedings of the National Academy of Sciences of the United States of America
Exploring the minimally frustrated energy landscape of unfolded ACBPJournal of Molecular Biology

2013

Conformational dynamics of single protein molecules studied by direct mechanical manipulation
Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2Nucleic Acids Research
Single-molecule folding mechanism of an EF-hand neuronal calcium sensorStructure

2012

Exploring folding pathways of single proteins using mechanical manipulation
A highly compliant protein native state with a spontaneous-like mechanical unfolding pathwayJournal of the American Chemical Society
The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺-activated stateJournal of Molecular Biology

2009

Effect of active site mutation on catalysis and backbone dynamics in a cold-adapted enzymeRAUST - Tímarit um raunvísindi og stærðfræði
Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopyFEBS Journal
Áhrif stökkbreytinga í hvarfstöð á hvötunarvirkni og staðbundinn hreyfanleika í stofnkeðju kuldavirks ensímsRAUST - Tímarit um raunvísindi og stærðfræði

2007

Measuring backbone dynamics in proteins using EPR spectroscopy

2006

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