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Sædís Sævarsdóttir - Professor

Sædís Sævarsdóttir

–

School of Health Sciences

Sædís Sævarsdóttir

Professor

Professor and Vice Head of the Faculty of Medicine, consultant in rheumatology at Landspitali University Hospital, project leader at deCODE genetics

Location
Sturlugata 8
Phone
5701900
Email
saedis [at] hi.is

Unit
Faculty of Medicine

Show Published works

2024

A partial loss-of-function variant in STAT6 protects against type 2 asthmaThe Journal of allergy and clinical immunology
Correction toNature
Gene-based burden tests of rare germline variants identify six cancer susceptibility genesNature Genetics
Genome-Wide Association Study of Accessory Atrioventricular PathwaysJAMA Cardiology
Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritisRheumatology (United Kingdom)
Legal obstacles jeopardise research in personalised medicine – experiences from a Nordic collaboration within rheumatologyScandinavian Journal of Public Health
Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk DeterminantsArthritis and Rheumatology
Sequence variants influencing the regulation of serum IgG subclass levelsNature Communications
Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid diseaseNature Communications
The correlation between CpG methylation and gene expression is driven by sequence variantsNature Genetics
Variants at the Interleukin 1 Gene Locus and PericarditisJAMA Cardiology

2025

Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritisJournal of internal medicine
In early rheumatoid arthritis, comorbidities do not explain the increased risk of failure to reach remission in patients with obesityRMD Open
Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein AntibodiesArthritis & rheumatology (Hoboken, N.J.)
The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritisRheumatology

2022

Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint ReplacementsArthritis & rheumatology (Hoboken, N.J.)
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndromeNature Communications
A genome-wide meta-analysis identifies 53 sequence variants associating with carpal tunnel syndrome
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B CellsFrontiers in Immunology
Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid ArthritisClinical Pharmacology and Therapeutics
Comorbidities and treatment patterns in early rheumatoid arthritisRMD Open
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?Arthritis Research and Therapy
Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestationsJoint Bone Spine
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2Communications Biology
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subsetAnnals of the rheumatic diseases.
Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritisArthritis Research and Therapy
Sleep problems in rheumatoid arthritis over 12 years from diagnosisRMD Open
The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritisRheumatology (Oxford, England)

2023

Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapyRMD Open
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethalityNature Communications
Disease-modifying antirheumatic drugs and risk of thyroxine-treated autoimmune thyroid disease in patients with rheumatoid arthritisJournal of Internal Medicine
Evaluation of an individually tailored smoking-cessation intervention for patients with rheumatoid arthritis in an outpatient clinicScandinavian Journal of Rheumatology
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammationAnnals of the Rheumatic Diseases
Large-scale plasma proteomics comparisons through genetics and disease associationsNature
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effectAnnals of the Rheumatic Diseases
Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethalityNature Communications
Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritisRMD Open
Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticariaCommunications Biology

2021

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid ArthritisFrontiers in Immunology
A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigoCommunications Biology
Comorbidities at diagnosis of rheumatoid arthritisRheumatology (Oxford, England)
Genetic variants associated with platelet count are predictive of human disease and physiological markersCommunications Biology
Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control studyArthritis Research and Therapy
Large-scale integration of the plasma proteome with genetics and diseaseNature Genetics
Mortality over 14 years in MTX-refractory patients randomized to a strategy of addition of infliximab or sulfasalazine and hydroxychloroquineRheumatology (United Kingdom)
Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid ArthritisArthritis Care and Research
Rheumatoid arthritis autoantibodies and their association with age and sexClinical and Experimental Rheumatology
Social stressors and risk of rheumatoid arthritis and their relationship to known modifiable risk factorsScandinavian Journal of Rheumatology
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in IcelandArthritis and Rheumatology
Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritisArthritis Research and Therapy

2020

Abatacept in rheumatoid arthritisArthritis Research and Therapy
Anti–Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid ArthritisArthritis & Rheumatology
An updated matrix to predict rapid radiographic progression of early rheumatoid arthritis patientsRheumatology (United Kingdom)
Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritisSeminars in Arthritis and Rheumatism
Does autoimmune thyroid disease affects rheumatoid arthritis disease activity or response to methotrexate?RMD Open
Drug Tolerant Anti-drug Antibody Assay for Infliximab Treatment in Clinical Practice Identifies Positive Cases EarlierFrontiers in Immunology
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid diseaseNature
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian womenNature Communications
Occupational physical workload and development of anti-collagen type II antibodies in rheumatoid arthritisClinical and Experimental Rheumatology
Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activityArthritis Research & Therapy
The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritisJournal of Internal Medicine

2019

Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritisScandinavian Journal of Rheumatology
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39Annals of the Rheumatic Diseases
Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritisRMD Open
Periodontal health and oral microbiota in patients with rheumatoid arthritisJournal of Clinical Medicine
Predicting risk for radiographic damage in rheumatoid arthritisCurrent Medical Research and Opinion
Serum biomarkers for prediction of response to methotrexate monotherapy in early rheumatoid arthritisJournal of Rheumatology
Smoking and response to rituximab in rheumatoid arthritisScandinavian Journal of Rheumatology

2018

Anti–Carbamylated Protein Antibodies and Higher Baseline Disease Activity in Rheumatoid Arthritis—A Replication Study in Three CohortsArthritis and Rheumatology
Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritisSeminars in Arthritis and Rheumatism
Risk of Thyroxine-Treated Autoimmune Thyroid Disease Associated With Disease Onset in Patients With Rheumatoid ArthritisJAMA network open

2017

A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate FailureArthritis and Rheumatology
Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-upAnnals of the Rheumatic Diseases
A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosusAnnals of the Rheumatic Diseases
Obesity is a strong predictor of worse clinical outcomes and treatment responses in early rheumatoid arthritisRMD Open
Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritisAnnals of the Rheumatic Diseases

2016

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort studyArthritis Research and Therapy
Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritisRMD Open
Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritisAnnals of the Rheumatic Diseases
Correlates of leisure time physical inactivity in a scandinavian populationJournal of Physical Activity and Health
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritisNature Communications
Développement d'une matrice de risque de la progression radiographique rapide à 1 an après diagnostic d'une polyarthrite rhumatoïde débutanteRevue du Rhumatisme (Edition Francaise)
Does a family history of RA influence the clinical presentation and treatment response in RA?Annals of the Rheumatic Diseases
Family history of rheumatoid arthritisNature Reviews Rheumatology
Remaining Pain in Early Rheumatoid Arthritis Patients Treated With MethotrexateArthritis Care and Research

2015

Brief reportArthritis and Rheumatology
Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritisAnnals of the Rheumatic Diseases
Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activityArthritis Research and Therapy
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritisAnnals of the Rheumatic Diseases
Infektioner kopplades till minskad risk för reumatoid artritLakartidningen
Parity influences the severity of ACPA-negative early rheumatoid arthritisArthritis Research and Therapy
Postmenopausal hormone therapy and the risk of rheumatoid arthritisEuropean Journal of Epidemiology
Pretreatment multi-biomarker disease activity score and radiographic progression in early RAAnnals of the Rheumatic Diseases
Recent infections are associated with decreased risk of rheumatoid arthritisAnnals of the Rheumatic Diseases
Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexateArthritis Research and Therapy

2014

Accelerating translational research by clinically driven development of an informatics platform-A case studyPLoS ONE
Association between life events and rheumatoid arthritisArthritis Care and Research
Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritisAnnals of the Rheumatic Diseases
Patients with regular physical activity before onset of rheumatoid arthritis present with milder diseaseAnnals of the Rheumatic Diseases
Response toAnnals of the Rheumatic Diseases
Thyroxin substitution and the risk of developing rheumatoid arthritis; Results from the Swedish population-based EIRA studyAnnals of the Rheumatic Diseases

2013

Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritisBMC Musculoskeletal Disorders
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritisAnnals of the Rheumatic Diseases
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid ArthritisPLoS Genetics

2012

In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully preventedAnnals of the Rheumatic Diseases
Influence of FCGR3A genotype on the therapeutic response to rituximab in rheumatoid arthritisBMJ Open
Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritisPharmacogenetics and Genomics
Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritisArthritis and Rheumatism

2011

Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokersArthritis Research and Therapy
Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitorsArthritis and Rheumatism
Predicting response to treatment in patients with rheumatoid arthritisEuropean Musculoskeletal Review
Predictors of response to methotrexate in early DMARD naïve rheumatoid arthritisAnnals of the Rheumatic Diseases

2010

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapyArthritis and Rheumatism

2008

Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in icelandic multicase systemic lupus erythematosus familiesArthritis and Rheumatism
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infectionClinical Infectious Diseases

2007

Mannan-binding lectin may facilitate the clearance of circulating immune complexes - Implications from a study on C2-deficient individualsClinical and Experimental Immunology
Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controlsJournal of Rheumatology

2006

kafli 13: Gigtsjúkdómar og klínísk ónæmisfræði
Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosusAnnals of the Rheumatic Diseases

2005

Afstada unglaekna og laeknanema til sérfraedináms á Islandi.Læknabladid
Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced riskJournal of Experimental Medicine
Postgraduate medical education in Iceland; medical students’ and residents’ attitudeLæknablaðið

2004

Human Plasma-Derived Mannose-Binding LectinScandinavian Journal of Immunology
The potential role of mannan-binding lectin in the clearance of self-components including immune complexesScandinavian Journal of Immunology

2001

Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective studyJournal of Rheumatology

Keywords for Specialisation:

Genetic epidemiology

Precision medicine

Personalised medicine

Rheumatoid arthritis

Systemic lupus erythematosus