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Sædís Sævarsdóttir - Professor

Sædís Sævarsdóttir

–

School of Health Sciences

Sædís Sævarsdóttir

Professor

Professor and Dean of the Faculty of Medicine, consultant in rheumatology at Landspitali University Hospital

Location
Læknagarður
Phone
5431000, 5254881
Email
saedis [at] hi.is

Unit
Faculty of Medicine

Published works

2026

Variant in a Taste Receptor Locus Tied to Changes in the Use of Insomnia MedicationBiological Psychiatry Global Open Science

2025

Association of matrix metalloproteinase 7 and the alpha-chain of fibrinogen at baseline with response to methotrexate at 3 months in patients with early rheumatoid arthritisBMC Rheumatology
The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritisRheumatology
Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein AntibodiesArthritis & rheumatology (Hoboken, N.J.)
In early rheumatoid arthritis, comorbidities do not explain the increased risk of failure to reach remission in patients with obesityRMD Open
Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritisJournal of internal medicine
Genome-wide association study and polygenic risk prediction of hypothyroidismNature Genetics
Autoantibody-defined subsets of patients with systemic lupus erythematosus associate with clinical manifestations, NCF2, and HLA DR3-DQ2 genotypesTranslational Research
African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus riskNature Genetics

2024

The correlation between CpG methylation and gene expression is driven by sequence variantsNature Genetics
A partial loss-of-function variant in STAT6 protects against type 2 asthmaThe Journal of allergy and clinical immunology
Variants at the Interleukin 1 Gene Locus and PericarditisJAMA Cardiology
Correction toNature
Sequence variants influencing the regulation of serum IgG subclass levelsNature Communications
Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk DeterminantsArthritis and Rheumatology
Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid diseaseNature Communications
Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritisRheumatology (United Kingdom)
Legal obstacles jeopardise research in personalised medicine – experiences from a Nordic collaboration within rheumatologyScandinavian Journal of Public Health
Genome-Wide Association Study of Accessory Atrioventricular PathwaysJAMA Cardiology
Gene-based burden tests of rare germline variants identify six cancer susceptibility genesNature Genetics

2023

Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethalityNature Communications
Large-scale plasma proteomics comparisons through genetics and disease associationsNature
Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritisRMD Open
Evaluation of an individually tailored smoking-cessation intervention for patients with rheumatoid arthritis in an outpatient clinicScandinavian Journal of Rheumatology
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effectAnnals of the Rheumatic Diseases
Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapyRMD Open
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammationAnnals of the Rheumatic Diseases
Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticariaCommunications Biology
Disease-modifying antirheumatic drugs and risk of thyroxine-treated autoimmune thyroid disease in patients with rheumatoid arthritisJournal of Internal Medicine
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethalityNature Communications

2022

Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid ArthritisClinical Pharmacology and Therapeutics
Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritisArthritis Research and Therapy
The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritisRheumatology (Oxford, England)
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subsetAnnals of the rheumatic diseases.
Sleep problems in rheumatoid arthritis over 12 years from diagnosisRMD Open
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndromeNature Communications
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subsetAnnals of the Rheumatic Diseases
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2Communications Biology
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B CellsFrontiers in Immunology
Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestationsJoint Bone Spine
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?Arthritis Research and Therapy
Comorbidities and treatment patterns in early rheumatoid arthritisRMD Open
A genome-wide meta-analysis identifies 53 sequence variants associating with carpal tunnel syndrome
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint ReplacementsArthritis & rheumatology (Hoboken, N.J.)

2021

The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in IcelandArthritis and Rheumatology
Rheumatoid arthritis autoantibodies and their association with age and sexClinical and Experimental Rheumatology
Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications Biology
A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigoCommunications Biology
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacementsArthritis and Rheumatology
Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid ArthritisArthritis Care and Research
Social stressors and risk of rheumatoid arthritis and their relationship to known modifiable risk factorsScandinavian Journal of Rheumatology
A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid ArthritisFrontiers in Immunology
Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control studyArthritis Research and Therapy
Genetic variants associated with platelet count are predictive of human disease and physiological markersCommunications Biology
Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritisArthritis Research and Therapy
Mortality over 14 years in MTX-refractory patients randomized to a strategy of addition of infliximab or sulfasalazine and hydroxychloroquineRheumatology (United Kingdom)
Comorbidities at diagnosis of rheumatoid arthritisRheumatology (Oxford, England)
Large-scale integration of the plasma proteome with genetics and diseaseNature Genetics

2020

The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritisJournal of Internal Medicine
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian womenNature Communications
An updated matrix to predict rapid radiographic progression of early rheumatoid arthritis patientsRheumatology (United Kingdom)
Drug Tolerant Anti-drug Antibody Assay for Infliximab Treatment in Clinical Practice Identifies Positive Cases EarlierFrontiers in Immunology
Occupational physical workload and development of anti-collagen type II antibodies in rheumatoid arthritisClinical and Experimental Rheumatology
Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activityArthritis Research & Therapy
Anti–Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid ArthritisArthritis & Rheumatology
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid diseaseNature
Abatacept in rheumatoid arthritisArthritis Research and Therapy
Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritisSeminars in Arthritis and Rheumatism
Does autoimmune thyroid disease affects rheumatoid arthritis disease activity or response to methotrexate?RMD Open

2019

Periodontal health and oral microbiota in patients with rheumatoid arthritisJournal of Clinical Medicine
Smoking and response to rituximab in rheumatoid arthritisScandinavian Journal of Rheumatology
Serum biomarkers for prediction of response to methotrexate monotherapy in early rheumatoid arthritisJournal of Rheumatology
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39Annals of the Rheumatic Diseases
Predicting risk for radiographic damage in rheumatoid arthritisCurrent Medical Research and Opinion
Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritisScandinavian Journal of Rheumatology
Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritisRMD Open

2018

Risk of Thyroxine-Treated Autoimmune Thyroid Disease Associated With Disease Onset in Patients With Rheumatoid ArthritisJAMA network open
Anti–Carbamylated Protein Antibodies and Higher Baseline Disease Activity in Rheumatoid Arthritis—A Replication Study in Three CohortsArthritis and Rheumatology
Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritisSeminars in Arthritis and Rheumatism

2017

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosusAnnals of the Rheumatic Diseases
Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritisAnnals of the Rheumatic Diseases
Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-upAnnals of the Rheumatic Diseases
Obesity is a strong predictor of worse clinical outcomes and treatment responses in early rheumatoid arthritisRMD Open
A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate FailureArthritis and Rheumatology

2016

Family history of rheumatoid arthritisNature Reviews Rheumatology
Développement d'une matrice de risque de la progression radiographique rapide à 1 an après diagnostic d'une polyarthrite rhumatoïde débutanteRevue du Rhumatisme (Edition Francaise)
Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritisAnnals of the Rheumatic Diseases
Correlates of leisure time physical inactivity in a scandinavian populationJournal of Physical Activity and Health
A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort studyArthritis Research and Therapy
Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritisRMD Open
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritisNature Communications
Does a family history of RA influence the clinical presentation and treatment response in RA?Annals of the Rheumatic Diseases
Remaining Pain in Early Rheumatoid Arthritis Patients Treated With MethotrexateArthritis Care and Research

2015

Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexateArthritis Research and Therapy
Brief reportArthritis and Rheumatology
Parity influences the severity of ACPA-negative early rheumatoid arthritisArthritis Research and Therapy
Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritisAnnals of the Rheumatic Diseases
Postmenopausal hormone therapy and the risk of rheumatoid arthritisEuropean Journal of Epidemiology
Pretreatment multi-biomarker disease activity score and radiographic progression in early RAAnnals of the Rheumatic Diseases
Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activityArthritis Research and Therapy
Infektioner kopplades till minskad risk för reumatoid artritLakartidningen
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritisAnnals of the Rheumatic Diseases
Recent infections are associated with decreased risk of rheumatoid arthritisAnnals of the Rheumatic Diseases

2014

Patients with regular physical activity before onset of rheumatoid arthritis present with milder diseaseAnnals of the Rheumatic Diseases
Response toAnnals of the Rheumatic Diseases
Association between life events and rheumatoid arthritisArthritis Care and Research
Accelerating translational research by clinically driven development of an informatics platform-A case studyPLoS ONE
Thyroxin substitution and the risk of developing rheumatoid arthritis; Results from the Swedish population-based EIRA studyAnnals of the Rheumatic Diseases
Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritisAnnals of the Rheumatic Diseases

2013

Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritisBMC Musculoskeletal Disorders
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid ArthritisPLoS Genetics
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritisAnnals of the Rheumatic Diseases

2012

Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritisPharmacogenetics and Genomics
Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritisArthritis and Rheumatism
Influence of FCGR3A genotype on the therapeutic response to rituximab in rheumatoid arthritisBMJ Open
In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully preventedAnnals of the Rheumatic Diseases

2011

Predicting response to treatment in patients with rheumatoid arthritisEuropean Musculoskeletal Review
Predictors of response to methotrexate in early DMARD naïve rheumatoid arthritisAnnals of the Rheumatic Diseases
Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokersArthritis Research and Therapy
Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitorsArthritis and Rheumatism

2010

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapyArthritis and Rheumatism

2008

Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infectionClinical Infectious Diseases
Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in icelandic multicase systemic lupus erythematosus familiesArthritis and Rheumatism

2007

Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controlsJournal of Rheumatology
Mannan-binding lectin may facilitate the clearance of circulating immune complexes - Implications from a study on C2-deficient individualsClinical and Experimental Immunology

2006

Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosusAnnals of the Rheumatic Diseases
kafli 13: Gigtsjúkdómar og klínísk ónæmisfræði

2005

Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced riskJournal of Experimental Medicine
Afstada unglaekna og laeknanema til sérfraedináms á Islandi.Læknabladid
Postgraduate medical education in Iceland; medical students’ and residents’ attitudeLæknablaðið

2004

The potential role of mannan-binding lectin in the clearance of self-components including immune complexesScandinavian Journal of Immunology
Human Plasma-Derived Mannose-Binding LectinScandinavian Journal of Immunology

2001

Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective studyJournal of Rheumatology

Keywords for Specialisation:

Genetic epidemiology

Precision medicine

Personalised medicine

Rheumatoid arthritis

Systemic lupus erythematosus